No impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladesh

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dc.contributor.authorChaney, Carlyeen
dc.contributor.authorBegum, Khurshidaen
dc.contributor.authorNúñez-de la Mora, Alejandraen
dc.contributor.authorSievert, Lynnette L.en
dc.contributor.authorMuttukrishna, Shanthien
dc.contributor.authorHarries, Victoriaen
dc.contributor.authorSharmeen, Taniyaen
dc.contributor.authorMurphy, Lornaen
dc.contributor.authorGunu, Richarden
dc.contributor.authorChowdhury, Osulen
dc.contributor.authorBentley, Gillian R.en
dc.contributor.funderCommonwealth Scholarship Commissionen
dc.contributor.funderNational Science Foundationen
dc.contributor.funderSigma Xiaen
dc.contributor.funderWolfson Research Institute for Health and Wellbeing, Durham Universityen
dc.date.accessioned2023-04-19T13:30:38Z
dc.date.available2023-04-19T13:30:38Z
dc.date.issued2021-06en
dc.description.abstractIntroduction: While many aspects of female ovarian function respond to environmental stressors, estradiol (E2) appears less sensitive to stressors than progesterone, except under extreme ecological conditions. However, earlier studies relied on saliva samples, considered less sensitive than blood. Here, we investigated E2 variation among 177 Bangladeshi and UK white women, aged 35-59, using single serum samples. Bangladeshi women either grew up in Sylhet, Bangladesh (exposed to poor sanitation, limited health care, and higher pathogen loads but not poor energy availability), or in the UK. Methods: We collected samples on days 4-6 of the menstrual cycle in menstruating women and on any day for post-menopausal women. Participants included: i) Bangladeshi sedentees (n=36), ii) Bangladeshis who migrated to the UK as adults (n=52), iii) Bangladeshis who migrated as children (n=40), and iv) UK white women matched for neighborhood residence to the migrants (n=49). Serum was obtained by venipuncture and analyzed using electrochemiluminescence. We collected anthropometrics and supplementary sociodemographic and reproductive data through questionnaires. We analyzed the data using multivariate regression. Results: E2 levels did not differ between migrant groups after controlling for age, BMI, physical activity, psychosocial stress, parity, and time since last birth (parous women). Paralleling results from salivary E2, serum E2 did not differ among women who experienced varying developmental conditions. Conclusion: Our results reinforce the hypothesis that E2 levels are stable under challenging environmental conditions. Interpopulation variation may only arise under chronic conditions of extreme nutritional scarcity, energy expenditure, and/or high disease burdens.en
dc.description.sponsorshipCommonwealth Scholarship Commission (Commonwealth Scholarship and Fellowship Plan); National Science Foundation (Grant Number: 0548393)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide23631en
dc.identifier.citationChaney, C., Begum, K., Núñez-de la Mora, A., Sievert, L. L., Muttukrishna, S., Harries, V., Sharmeen, T., Murphy, L., Gunu, R., Chowdhury, O. and Bentley, G. R. (2021) 'No impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladesh', American Journal of Human Biology, 34(3), e23631 (12pp). doi: 10.1002/ajhb.23631en
dc.identifier.doi10.1002/ajhb.23631en
dc.identifier.eissn1520-6300en
dc.identifier.endpage12en
dc.identifier.issn1042-0533en
dc.identifier.issued3en
dc.identifier.journaltitleAmerican Journal of Human Biologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14394
dc.identifier.volume34en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.ispartofAmerican Journal of Human Biologyen
dc.rights© 2021, Wiley Periodicals LLC. This is the peer reviewed version of the following item: Chaney, C., Begum, K., Núñez-de la Mora, A., Sievert, L. L., Muttukrishna, S., Harries, V., Sharmeen, T., Murphy, L., Gunu, R., Chowdhury, O. and Bentley, G. R. (2021) 'No impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladesh', American Journal of Human Biology, 34(3), e23631 (12pp), doi: 10.1002/ajhb.23631, which has been published in final form at https://doi.org/10.1002/ajhb.23631 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectSerum estradiolen
dc.subjectMigrationen
dc.subjectBangladeshi womenen
dc.subjectDevelopmental conditionsen
dc.subjectReproductive functionen
dc.titleNo impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladeshen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue3en
oaire.citation.volume34en
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