Comparison of a novel methadone rotation method with other commonly used methods

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dc.contributor.authorCunningham, Elaineen
dc.contributor.authorDiBiagio, Nicoleen
dc.contributor.authorO’Connell, Florryen
dc.contributor.authorFlannery, Maedhbhen
dc.contributor.authorCronin, Michaelen
dc.contributor.authorMurphy, Marieen
dc.contributor.authorO’Leary, Mary Janeen
dc.contributor.authorKiely, Fionaen
dc.contributor.authorLowney, Aoife C.en
dc.date.accessioned2025-04-02T15:21:51Z
dc.date.available2025-04-02T15:21:51Z
dc.date.issued2024en
dc.description.abstractObjectives To compare a novel method of methadone rotation used in a specialist palliative care inpatient unit (SPCU) in Cork, Ireland, with rapid titration methods using Perth and Brisbane Protocols as well as the Edmonton method of methadone rotation. Methods A retrospective chart review was performed in March–June 2022. All patients who completed rotation to methadone during 2018–2019 in the SPCU were included. 2018–2019 was selected to study a population not affected by the coronavirus pandemic. Oral morphine equivalent (OME) was calculated using the opioid conversion chart. From the OME, the expected daily methadone dose was calculated using the Perth, Brisbane and Edmonton methods. These figures were then compared directly with the actual methadone doses achieved using our dosing schedule. Results A comparison of the expected doses using the Perth and Brisbane rapid titration protocols and stable daily dose achieved revealed that the stable methadone dose was significantly lower than both rapid titration protocols (p=<0.0001) and (p=0.0035, respectively). However, a comparison of the expected dose using the Edmonton method and the dose achieved did not determine any significant difference (p=0.7602). Conclusions This is the first evaluation of a novel Irish method of methadone rotation and demonstrates a lower overall daily methadone dose compared with established protocols.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCunningham, E., DiBiagio, N., O’ Connell, F., Flannery, M., Cronin, M., Murphy, M., O’Leary, M.J., Kiely, F. and Lowney, A.C. (2024) ‘Comparison of a novel methadone rotation method with other commonly used methods’, BMJ Supportive & Palliative Care, p. spcare-2024-005147. https://doi.org/10.1136/spcare-2024-005147en
dc.identifier.doihttps://doi.org/10.1136/spcare-2024-005147en
dc.identifier.eissn2045-4368en
dc.identifier.issn2045-435Xen
dc.identifier.journaltitleBMJ Supportive & Palliative Careen
dc.identifier.urihttps://hdl.handle.net/10468/17227
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.rights© 2024, the Author(s). Published by BMJ Publishing Group Ltd. This article has been accepted for publication in BMJ Supportive & Palliative Care, 2024 following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/spcare-2024-005147en
dc.subjectPainen
dc.subjectPalliative careen
dc.subjectDrug administrationen
dc.titleComparison of a novel methadone rotation method with other commonly used methodsen
dc.typeArticle (peer-reviewed)en
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