Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

Kumar, Vydula P.; Gupta, Manoj K.; Horgan, Conor; O'Sullivan, Timothy P.

Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

dc.contributor.author	Kumar, Vydula P.
dc.contributor.author	Gupta, Manoj K.
dc.contributor.author	Horgan, Conor
dc.contributor.author	O'Sullivan, Timothy P.
dc.contributor.funder	Irish Research Council	en
dc.contributor.funder	Seventh Framework Programme	en
dc.date.accessioned	2021-08-17T10:41:21Z
dc.date.available	2021-08-17T10:41:21Z
dc.date.issued	2018-04-27
dc.date.updated	2021-08-17T10:28:57Z
dc.description.abstract	The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.	en
dc.description.sponsorship	Irish Research Council (Government of Ireland Postgraduate Research Scholarship GOIPG/2017/1111)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Kumar, V. P., Gupta, M. K., Horgan, C. and O'Sullivan, T. P. (2018) 'Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction', Tetrahedron Letters, 59(22), pp. 2193-2195. doi: 10.1016/j.tetlet.2018.04.071	en
dc.identifier.doi	10.1016/j.tetlet.2018.04.071	en
dc.identifier.endpage	2195	en
dc.identifier.issn	0040-4039
dc.identifier.issued	22	en
dc.identifier.journaltitle	Tetrahedron Letters	en
dc.identifier.startpage	2193	en
dc.identifier.uri	https://hdl.handle.net/10468/11747
dc.identifier.volume	59	en
dc.language.iso	en	en
dc.publisher	Elsevier Ltd.	en
dc.relation.project	info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/272194/EU/Towards an enantioselective synthesis of Plakortide P and its application to the development of drugs for the treatment of Chagas disease/PLAKORTIDE	en
dc.rights	© 2018, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Alkyne zipper reaction	en
dc.subject	Diffusible Signal Factor	en
dc.subject	Partial hydrogenation	en
dc.subject	Therapy	en
dc.title	Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction	en
dc.type	Article (peer-reviewed)	en