Characterisation of the consequences of maternal immune activation on distinct cell populations in the developing rat spinal cord

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dc.contributor.authorAnderson, Rebecca C.en
dc.contributor.authorO'Keeffe, Gerard W.en
dc.contributor.authorMcDermott, Kieran W.en
dc.contributor.funderUniversity of Limericken
dc.date.accessioned2024-05-14T15:17:17Z
dc.date.available2024-05-14T15:17:17Z
dc.date.issued2022-07-09en
dc.description.abstractMaternal immune activation (MIA) during gestation has been implicated in the development of neurological disorders such as schizophrenia and autism. Epidemiological studies have suggested that the effect of MIA may depend on the gestational timing of the immune challenge and the region of the central nervous system (CNS) in question. This study investigated the effects of MIA with 100 μg/kg lipopolysaccharide at either Embryonic days (E)12 or E16 on the oligodendrocytes, microglia and astrocytes of the offspring spinal cord. At E16, MIA decreased the number of olig2+ and Iba-1+ cells in multiple grey and white matter regions of the developing spinal cord 5 h after injection. These decreases were not observed at postnatal day 14. In contrast, MIA at E12 did not alter Olig2+ or Iba-1+ cell number in the developing spinal cord 5 h after injection, however, Olig2+ cell number was decreased in the ventral grey matter of the P14 spinal cord. No changes were observed in glial fibrillary acidic protein (GFAP) expression at P14 following MIA at either E12 or E16. These data suggest that E16 may be a window of immediate vulnerability to MIA during spinal cord development, however, the findings also suggest that the developmental process may be capable of compensation over time. Potential changes in P14 animals following the challenge at E12 are indicative of the complexity of the effects of MIA during the developmental process.en
dc.description.sponsorshipUniversity of Limerick (Anatomical Society and The University of Limerick School of Medicine)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAnderson, R.C., O’Keeffe, G.W. and McDermott, K.W. (2022) ‘Characterisation of the consequences of maternal immune activation on distinct cell populations in the developing rat spinal cord’, Journal of Anatomy, 241(4), pp. 938–950. Available at: https://doi.org/10.1111/joa.13726en
dc.identifier.doihttps://doi.org/10.1111/joa.13726en
dc.identifier.endpage950en
dc.identifier.issn0021-8782en
dc.identifier.issn1469-7580en
dc.identifier.issued4en
dc.identifier.journaltitleJournal of Anatomyen
dc.identifier.startpage938en
dc.identifier.urihttps://hdl.handle.net/10468/15864
dc.identifier.volume241en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofJournal of Anatomyen
dc.rights© 2022 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAstrogliaen
dc.subjectCellular developmenten
dc.subjectDevelopmenten
dc.subjectMaternal immune activationen
dc.subjectMaternal infectionen
dc.subjectMicrogliaen
dc.subjectNeurodevelopmenten
dc.subjectOligodendrocytesen
dc.subjectSpinal corden
dc.titleCharacterisation of the consequences of maternal immune activation on distinct cell populations in the developing rat spinal corden
dc.typeArticle (peer-reviewed)en
oaire.citation.issue4en
oaire.citation.volume241en
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