Assessment of sonographic ovarian volume as a potential predictor of polycystic ovarian syndrome (PCOS): a hospital-based cross-sectional study

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dc.contributor.authorAli, Barbar
dc.contributor.authorHadadi, Ibrahim
dc.contributor.authorAdam, Mohamed
dc.contributor.authorFaqihi, Wael Ali
dc.contributor.authorSayed, Mohammad
dc.contributor.authorSultan A., Alotaibi
dc.contributor.authorAwadia, Gareeballah
dc.contributor.authorEngland, Andrew
dc.date.accessioned2026-05-18T13:50:01Z
dc.date.available2026-05-18T13:50:01Z
dc.date.issued2025-08-04
dc.description© 2026, The Author(s). Published by Bentham Science Publishers. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractIntroduction: Polycystic ovarian syndrome (PCOS) is a prevalent endocrine and metabolic disorder commonly associated with obesity and reproductive morbidities. The relationship between ovarian volume and BMI as well as ovarian morphology was therefore examined in this study to assess whether sonographic ovarian volume can serve as a supportive parameter in predicting PCOS in clinical practice. Methods: A hospital-based cross-sectional study of 100 women aged 20–40 years was conducted at the University of Lahore Teaching Hospital from December 2023 to September 2024. Participants were stratified according to normal weight (BMI < 25 kg/m2) and elevated BMI (BMI ≥ 25 kg/m2) groups with healthy and PCOS as subgroups within each group. Results: The left ovarian volume in PCOS patients was significantly larger than that in women without PCOS (mean 13.5 mL (SD 3.6) vs 10.4 mL (SD 1.9), P < 0.05). Likewise, the mean follicle size in the left ovary was also significantly larger in women with PCOS than in normal controls, 6.3 mm (SD 1.7) and 5.6 mm (SD 1.1), respectively (P < 0.05). PCOS showed a significant association with amenorrhea (85%) and acne (66%); however, 59% of participants showed hirsutism which was not significant. Discussion: The observed asymmetry in ovarian volume and the influence of BMI suggest underlying physiological variability. However, the absence of hormonal and metabolic data limits the interpretation, warranting cautious application of these findings. Conclusion: Ovarian volume alone is not a reliable diagnostic marker for PCOS. While the left ovary showed significant differences, the inconsistent findings support the need for a combined clinical, biochemical, and sonographic approach.en
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dc.format.extent3760367
dc.identifier.authororcidAli, Barbar
dc.identifier.authororcidHadadi, Ibrahim
dc.identifier.authororcidAdam, Mohamed
dc.identifier.authororcidFaqihi, Wael Ali
dc.identifier.authororcidSayed, Mohammad
dc.identifier.authororcidSultan A., Alotaibi
dc.identifier.authororcidAwadia, Gareeballah
dc.identifier.authororcidEngland, Andrew§0000-0001-6333-7776
dc.identifier.citationAli, B, Hadadi, I, Adam, M, Faqihi, W A, Sayed, M, Sultan A., A, Awadia, G & England, A 2025, 'Assessment of sonographic ovarian volume as a potential predictor of polycystic ovarian syndrome (PCOS): a hospital-based cross-sectional study', Endocrine, Metabolic and Immune Disorders - Drug Targets, vol. 26. https://doi.org/10.2174/0118715303396709250721152449
dc.identifier.doi10.2174/0118715303396709250721152449
dc.identifier.issn1871-5303
dc.identifier.journaltitleEndocrine, Metabolic and Immune Disorders - Drug Targets
dc.identifier.otherORCID: /0000-0001-6333-7776/work/215061836
dc.identifier.urihttps://hdl.handle.net/10468/18776
dc.identifier.urlhttps://www.scopus.com/pages/publications/105038394906
dc.identifier.urlhttps://openalex.org/W4413030649
dc.identifier.volume26
dc.language.isoeng
dc.rightscc_by
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectAmenorrhea
dc.subjectBiology
dc.subjectBody mass index
dc.subjectCross-sectional study
dc.subjectEndocrine system
dc.subjectEndocrinology
dc.subjectGenetics
dc.subjectGynecology
dc.subjectHirsutism
dc.subjectHormone
dc.subjectInsulin resistance
dc.subjectInternal medicine
dc.subjectMedicine
dc.subjectObesity
dc.subjectObstetrics
dc.subjectPathology
dc.subjectPhysiology
dc.subjectPolycystic ovary
dc.subjectPregnancy
dc.subject[Medicine]
dc.titleAssessment of sonographic ovarian volume as a potential predictor of polycystic ovarian syndrome (PCOS): a hospital-based cross-sectional studyen
dc.typeArticle (Peer reviewed)
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