Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota

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dc.contributor.authorTarracchini, Chiaraen
dc.contributor.authorLordan, Cathyen
dc.contributor.authorMilani, Christianen
dc.contributor.authorMoreira, Luiza P. D.en
dc.contributor.authorAlabedallat, Qusai M.en
dc.contributor.authorde Moreno de LeBlanc, Alejandraen
dc.contributor.authorTurroni, Francescaen
dc.contributor.authorLugli, Gabriele Andreaen
dc.contributor.authorMancabelli, Leonardoen
dc.contributor.authorLonghi, Giuliaen
dc.contributor.authorBrennan, Lorraineen
dc.contributor.authorMahony, Jenniferen
dc.contributor.authorLeBlanc, Jean Guyen
dc.contributor.authorNilaweera, Kanishka N.en
dc.contributor.authorCotter, Paul D.en
dc.contributor.authorvan Sinderen, Douween
dc.contributor.authorVentura, Marcoen
dc.contributor.editorFederico Reyen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2025-07-15T13:23:37Z
dc.date.available2025-07-15T13:23:37Z
dc.date.issued2025-04-02en
dc.description.abstractIn recent years, exhaustive efforts have been made to dissect the composition of gut-associated microbial communities and associated interactions with their human host, which are thought to play a crucial role in host development, physiology, and metabolic functions. Although such studies were initially focused on the description of the compositional shifts in the microbiota that occur between different health conditions, more recently, they have provided key insights into the functional and metabolic contributions of the gut microbiota to overall host physiology. In this context, an important metabolic activity of the human gut microbiota is believed to be represented by the synthesis of various vitamins that may elicit considerable benefits to human health. A growing body of scientific literature is now available relating to (predicted) bacterial vitamin biosynthetic abilities, with ever-growing information concerning the prevalence of these biosynthetic abilities among members of the human microbiota. This review is aimed at disentangling if and how cooperative trophic interactions of human microbiota members contribute to vitamin production, and if such, gut microbiota-mediated vitamin production varies according to different life stages. Moreover, it offers a brief exploration of how different diets may influence vitamin production by shaping the overall composition and metabolic activity of the human gut microbiota while also providing preliminary insights into potential correlations between human microbiota-associated vitamin production and the occurrence of human diseases and/or metabolic disorders.en
dc.description.sponsorshipEuropean Commission (NextGeneration EU, PNRR-M4C2- I1.1, PRIN 2022 - Project Code 20229LEB99 - CUP Code 1711 D53D23014150006)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00184-23en
dc.identifier.citationTarracchini, C., Lordan, C., Milani, C., Moreira, L. P., Alabedallat, Q. M., de Moreno de LeBlanc, A., Turroni, F., Lugli, G. A., Mancabelli, L., Longhi, G., Brennan, L., Mahony, J., LeBlanc, J. G., Nilaweera, K. N., Cotter, P. D., van Sinderen, D. and Ventura, M. (2025) 'Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota', Microbiology and Molecular Biology Reviews, 89(2), e00184-23. https://doi.org/10.1128/mmbr.00184-23en
dc.identifier.doi10.1128/mmbr.00184-23en
dc.identifier.eissn1098-5557en
dc.identifier.issn1092-2172en
dc.identifier.issued2en
dc.identifier.journaltitleMicrobiology and Molecular Biology Reviewsen
dc.identifier.urihttps://hdl.handle.net/10468/17705
dc.identifier.volume89en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofMicrobiology and Molecular Biology Reviewsen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme::Fixed Call/16/SP/3827/IE/Determinants of Mother-to-Infant Transfer of Microbiota/en
dc.rights© 2025, American Society for Microbiology.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiomeen
dc.subjectMetagenomicsen
dc.subjectMicrobe-microbe interactionen
dc.titleVitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiotaen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue2en
oaire.citation.volume89en
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