Sodium aspirin salts: crystallization and characterization

Simple item page
dc.contributor.authorBúdová, Miroslava
dc.contributor.authorSkořepová, Eliška
dc.contributor.authorJan, Čejka
dc.contributor.funderGrantová Agentura České Republikyen
dc.date.accessioned2020-02-20T15:24:36Z
dc.date.available2020-02-20T15:24:36Z
dc.date.issued2018-07-09
dc.description.abstractAcetylsalicylic acid (trade name aspirin) is a well-known drug with antipyretic and analgesic effects. Mixtures that benefit from better solubility of its sodium salt have been sold for almost 90 years. Currently, several drug products are available with sodium aspirin as their active ingredient, but, until now, its crystal structure remained unknown. We have investigated the multicomponent system of sodium acetylsalicylate with the following results: an anhydrate and a dihydrate of a 1:1 salt were identified together with a hemihydrate of a 2:1 salt. Crystal structures of all forms were solved by single-crystal X-ray diffraction. The structural changes upon desolvation were studied by simultaneous thermogravimetric/differential scanning calorimetry supported by X-ray powder diffraction. The crystal structures were compared to those of all up-to-date published crystal structures of aspirin salts. Both of the hydrated sodium salts belong to the same isostructural family, while the anhydrate crystallizes with a unique packing of the acetylsalicylate anions.en
dc.description.sponsorshipGrantová Agentura České Republiky (Czech Science Foundation (GA Č R) project, Grant No. 16-10035S)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBúdová, M., Skořepová, E. and Jan, Č. (2018) 'Sodium Aspirin Salts: Crystallization and Characterization', Crystal Growth & Design, 18(9), pp. 5287-5294. doi: 10.1021/acs.cgd.8b00718en
dc.identifier.doi10.1021/acs.cgd.8b00718en
dc.identifier.endpage5294en
dc.identifier.issn1528-7483
dc.identifier.issn1528-7505
dc.identifier.issued9en
dc.identifier.journaltitleCrystal Growth & Desigen
dc.identifier.startpage5287en
dc.identifier.urihttps://hdl.handle.net/10468/9677
dc.identifier.volume18en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acs.cgd.8b00718
dc.rights© 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.cgd.8b00718en
dc.subjectSaltsen
dc.subjectCrystal structureen
dc.subjectMoleculesen
dc.subjectSodium cationsen
dc.subjectPolymorphismen
dc.subjectHydratesen
dc.subjectPolymorphic transformationen
dc.titleSodium aspirin salts: crystallization and characterizationen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
6359.pdf
Size:
1.52 MB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Chemistry - Journal Articles
Analytical & Biological Chemistry Research Facility - Journal Articles