Current status and future prospects of marine natural products (MNPs) as antimicrobials

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dc.contributor.authorChoudhary, Alka
dc.contributor.authorNaughton, Lynn
dc.contributor.authorMontánchez, Itxaso
dc.contributor.authorDobson, Alan D. W.
dc.contributor.authorRai, Dilip K.
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.date.accessioned2017-10-18T09:40:14Z
dc.date.available2017-10-18T09:40:14Z
dc.date.issued2017
dc.description.abstractThe marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine (food institutional Research Measure (FIRM 11/F/009)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid272
dc.identifier.citationChoudhary, A., Naughton, L., Montánchez, I., Dobson, A. and Rai, D. (2017) 'Current status and future prospects of marine natural products (MNPs) as antimicrobials', Marine Drugs, 15(9), 272 (42pp). doi: 10.3390/md15090272en
dc.identifier.doi10.3390/md15090272
dc.identifier.endpage42
dc.identifier.issn1660-3397
dc.identifier.issued9
dc.identifier.journaltitleMarine Drugsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/4891
dc.identifier.volume15
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttp://www.mdpi.com/1660-3397/15/9/272
dc.rights© 2017, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAntimicrobialen
dc.subjectMarine natural products (MNPs)en
dc.subjectSecondary metabolitesen
dc.subjectAntibacterialen
dc.subjectAntifungalen
dc.subjectGenome miningen
dc.titleCurrent status and future prospects of marine natural products (MNPs) as antimicrobialsen
dc.typeArticle (peer-reviewed)en
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