An international consensus list of potentially clinically significant drug-drug interactions in older people

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dc.contributor.authorAnrys, Paulineen
dc.contributor.authorPetit, Anne-Elisabethen
dc.contributor.authorThevelin, Stefanieen
dc.contributor.authorSallevelt, Bastiaanen
dc.contributor.authorDrenth, Claraen
dc.contributor.authorSoiza, Roy L.en
dc.contributor.authorCorrea-Pérez, Andreaen
dc.contributor.authorDalleur, Oliviaen
dc.contributor.authorDe Brauwer, Isabelleen
dc.contributor.authorPetrovic, Mirkoen
dc.contributor.authorColeman, Jamie J.en
dc.contributor.authorDalton, Kieranen
dc.contributor.authorO'Mahony, Denisen
dc.contributor.authorLöwe, Axelen
dc.contributor.authorThürig, Silvanen
dc.contributor.authorGudmundsson, Aðalsteinnen
dc.contributor.authorCherubini, Antonioen
dc.contributor.authorPanos, Agapiosen
dc.contributor.authorMavridis, Dimitrisen
dc.contributor.authorRodondi, Nicolasen
dc.contributor.authorSpinewine, Anneen
dc.date.accessioned2024-12-19T12:38:39Z
dc.date.available2024-12-19T12:38:39Z
dc.date.issued2021-09-24en
dc.description.abstractObjectives: We aimed to establish an explicit list of potentially clinically significant drug-drug interactions (DDIs) in people aged ≥65 years. Design: A preliminary list of potentially clinically significant DDIs was compiled, based on 154 DDIs identified from literature review. Subsequently, a 2-round online Delphi survey was undertaken with a multidisciplinary expert panel. A consensus meeting and a final round were conducted to validate the final DDI list and the scope of information provided. Setting and Participants: Twenty nine experts, including geriatricians and clinical pharmacists from 8 European countries. Measures: For each DDI, in the first 2 rounds, experts were asked to score the severity of potential harm on a 5-point Likert-type scale. DDIs were directly included on the final list if the median score was 4 (major) or 5 (catastrophic). DDIs with a median score of 3 (moderate) were discussed at a consensus meeting and included if ≥75% of participants voted for inclusion in the final round. Results: Consensus was achieved on 66 potentially clinically significant DDIs (28 had a median score of 4/5 and 48 of 3 in the Delphi survey). Most concerned cardiovascular, antithrombotic, and central nervous system drugs. The final list includes information on the mechanism of interaction, harm, and management. Treatment modification is recommended for three-quarters of DDIs. Conclusion and Implications: We validated a list of potentially clinically significant DDIs in older people, which can be used in clinical practice and education to support identification and management of DDIs or to assess prevalence in epidemiologic and intervention studies.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAnrys, P., Petit, A. E., Thevelin, S., Sallevelt, B., Drenth, C., Soiza, R. L., Correa-Pérez, A., Dalleur, O., De Brauwer, I., Petrovic, M., Coleman, J. J., Dalton, K., O'Mahony, D., Löwe, A., Thürig, S., Gudmundsson, A., Cherubini, A., Panos, A., Mavridis, D., Rodondi, N. and Spinewine, A. (2021) 'An international consensus list of potentially clinically significant drug-drug interactions in older people', Journal of the American Medical Directors Association, 22(10), pp.2121-2133. https://doi.org/10.1016/j.jamda.2021.03.019en
dc.identifier.doi10.1016/j.jamda.2021.03.019en
dc.identifier.endpage2133en
dc.identifier.issn1525-8610en
dc.identifier.issued10en
dc.identifier.journaltitleJournal of the American Medical Directors Associationen
dc.identifier.startpage2121en
dc.identifier.urihttps://hdl.handle.net/10468/16742
dc.identifier.volume22en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2021, AMDA - The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDrug-drug interactions (DDIs)en
dc.subjectOlder peopleen
dc.subject~Pharmacy - Journal Articles~en
dc.titleAn international consensus list of potentially clinically significant drug-drug interactions in older peopleen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue10en
oaire.citation.volume22en
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