10 year cumulative diagnostic radiation exposure after acute pancreatitis: a retrospective comparison of acute interstitial oedematous and necrotising pancreatitis

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dc.contributor.authorChleirigh, N.N.
dc.contributor.authorO'Broin, Evan R.
dc.contributor.authorShet, S.
dc.contributor.authorLee, R.
dc.contributor.authorde Kock, L.
dc.contributor.authorKakish, E.
dc.contributor.authorRyan, David J.
dc.contributor.authorMaher, M.M.
dc.date.accessioned2026-05-18T11:00:02Z
dc.date.available2026-05-18T11:00:02Z
dc.date.issued2026-03-26
dc.description.abstractPurpose Computed tomography (CT) plays a pivotal role in the diagnosis, severity assessment and recognition of complications in patients with acute pancreatitis (AP). Exposure to cumulative radiation dose increases the risk of malignancy. This study aims to retrospectively investigate imaging utilisation patterns in AP and quantify cumulative effective dose (CED), and identify predictors of high radiation exposure. Methods Adults admitted with AP between 2012 and 2013 were retrospectively reviewed. All imaging over the subsequent 10 years was analysed, and CED was calculated from dose reports or estimated using diagnostic reference levels where required. High exposure was defined as CED > 100 mSv, a dose associated with an increased lifetime risk of malignancy. Results One hundred-thirteen patients were included with 3022 imaging studies (92 acute interstitial oedematous pancreatitis (AIOP), 21 necrotising pancreatitis (NP)), CT comprised approximately 18% of examinations but delivered > 85% of radiation. Median (IQR) CED was 19.5 mSv for AIOP and 43.3 mSv for NP (p = 0.004). CED exceeded 100 mSv in 4.3% (4/92) of AIOP and 19% (4/21) of NP patients. Overall, 7% (8/113) of the cohort exceeded a CED of 100 mSv. No significant associations were found between CED and aetiology, pseudocyst formation, or mortality. Conclusion Over a decade of follow-up, 7% of patients with acute pancreatitis exceeded the 100 mSv threshold, with CT accounting for the vast majority of exposure. Necrotising pancreatitis was associated with significantly higher cumulative doses than interstitial disease. Given that up to 30% of patients develop recurrent pancreatitis, strategies to minimize radiation exposure are essential. Optimisation of CT protocols and wider use of non-ionising modalities, including magnetic resonance imaging (MRI) and endoscopic ultrasound where appropriate, may help balance diagnostic accuracy with radiation stewardship.en
dc.description.versionPublished Version
dc.format.extent8
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid276
dc.identifier.authororcidChleirigh, N.N.
dc.identifier.authororcidO'Broin, Evan R.
dc.identifier.authororcidShet, S.
dc.identifier.authororcidLee, R.
dc.identifier.authororcidde Kock, L.
dc.identifier.authororcidKakish, E.
dc.identifier.authororcidRyan, David J.
dc.identifier.authororcidMaher, M.M.
dc.identifier.citationChleirigh, N N, O'Broin, E R, Shet, S, Lee, R, de Kock, L, Kakish, E, Ryan, D J & Maher, M M 2026, '10 year cumulative diagnostic radiation exposure after acute pancreatitis: a retrospective comparison of acute interstitial oedematous and necrotising pancreatitis', BMC Gastroenterology, vol. 26, no. 1, 276. https://doi.org/10.1186/s12876-026-04735-3
dc.identifier.doi10.1186/s12876-026-04735-3
dc.identifier.issn1471-230X
dc.identifier.issued1
dc.identifier.journaltitleBMC Gastroenterology
dc.identifier.otherRIS: urn:96D11A894F67D51BF3F8D63B95CB7A72
dc.identifier.urihttps://hdl.handle.net/10468/18775
dc.identifier.volume26
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.relation.urihttps://www.scopus.com/pages/publications/105038086671
dc.relation.urihttps://www.scopus.com/pages/publications/105038086671?origin=resultslist
dc.rights© 2026, the Authors . Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.statusPeer reviewed
dc.subjectAcute hemorrhagic pancreatitis
dc.subjectAcute interstitial pancreatitis
dc.subjectAcute pancreatitis
dc.subjectAdult
dc.subjectAnimal tissue
dc.subjectArticle
dc.subjectClinical article
dc.subjectControlled study
dc.subjectDiagnosis
dc.subjectEdema
dc.subjectEffective dose
dc.subjectFemale
dc.subjectHuman
dc.subjectMale
dc.subjectMiddle aged
dc.subjectNecrotizing pancreatitis
dc.subjectPancreas necrosis
dc.subjectPancreatitis
dc.subjectRadiation exposure
dc.subjectRetrospective study
dc.subject[Medicine]
dc.title10 year cumulative diagnostic radiation exposure after acute pancreatitis: a retrospective comparison of acute interstitial oedematous and necrotising pancreatitisen
dc.typeArticle (peer-reviewed)
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