Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis

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dc.contributor.authorOró-Nolla, Martí
dc.contributor.authorSun, Melody Cui
dc.contributor.authorReilly, Thomas
dc.contributor.authorAnandarajah, Julia
dc.contributor.authorOtálora-Alcaraz, Almudena
dc.contributor.authorCostelloe, Lisa
dc.contributor.authorKearney, Hugh
dc.contributor.authorMagee, Richard
dc.contributor.authorNolan, Yvonne M
dc.contributor.authorDowner, Eric J
dc.contributor.funderConsortium of National and University Libraries
dc.date.accessioned2026-05-18T15:00:02Z
dc.date.available2026-05-18T15:00:02Z
dc.date.issued2026-03-12
dc.description.abstractOBJECTIVE: Dual-specificity phosphatase 1 (DUSP1) is a negative regulator of mitogen-activated protein kinase (MAPK) activity, and a player in the control of glial function. Several disease models have identified that the expression of DUSP1 is altered in tissue samples, which may contribute to disease pathogenesis. Using post-mortem brain tissue from a cohort of progressive multiple sclerosis (MS) cases, this study set out to determine if the expression of DUSP1 is altered in the brain in MS. METHODS: We employed the use of a combination of PCR, western immunoblotting and immunohistochemical analysis to profile the expression of DUSP1. RESULTS: Data presented herein indicate that DUSP1 is significantly downregulated at gene and protein level in MS white matter tissue, when compared to samples from a non-MS control cohort. We also identify that DUSP1 is expressed on Iba1 + cells in the brain and that ITGAM (CD11b) expression is elevated in white matter in progressive MS. CONCLUSIONS: These findings provide evidence that DUSP1 is dysregulated centrally in CNS white matter in progressive MS.en
dc.description.sponsorshipOpen Access funding provided by the IReL Consortium. This work has been supported by funding from the Provosts PhD Project Awards at Trinity College Dublin, the Henry Cooke Drury Fund, School of Medicine, Trinity College Dublin, and grants from Research Ireland and Health Research Board. Tissue samples were obtained from the UK MS and Parkinson’s Tissue Bank at Imperial College London, and from the Dublin Brain Bank at Beaumont Hospital Dublin. This work has been supported by funding from the Provosts PhD Project Awards at Trinity College Dublin, the Henry Cooke Drury Fund, School of Medicine, Trinity College Dublin, and grants from Research Ireland and the Health Research Board. Tissue samples were obtained from the UK MS and Parkinson’s Tissue Bank at Imperial College London, and from the Dublin Brain Bank at Beaumont Hospital Dublin.
dc.description.versionPublished Version
dc.format.extent5
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid338
dc.identifier.authororcidOró-Nolla, Martí
dc.identifier.authororcidSun, Melody Cui
dc.identifier.authororcidReilly, Thomas
dc.identifier.authororcidAnandarajah, Julia
dc.identifier.authororcidOtálora-Alcaraz, Almudena
dc.identifier.authororcidCostelloe, Lisa
dc.identifier.authororcidKearney, Hugh
dc.identifier.authororcidMagee, Richard
dc.identifier.authororcidNolan, Yvonne M§0000-0003-2426-234X
dc.identifier.authororcidDowner, Eric J
dc.identifier.citationOró-Nolla, M, Sun, M C, Reilly, T, Anandarajah, J, Otálora-Alcaraz, A, Costelloe, L, Kearney, H, Magee, R, Nolan, Y M & Downer, E J 2026, 'Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis', Neurological Sciences, vol. 47, no. 4, 338. https://doi.org/10.1007/s10072-026-08944-2
dc.identifier.doi10.1007/s10072-026-08944-2
dc.identifier.issn1590-1874
dc.identifier.issued4
dc.identifier.journaltitleNeurological Sciences
dc.identifier.otherPubMedCentral: PMC12979298
dc.identifier.otherORCID: /0000-0003-2426-234X/work/215062486
dc.identifier.urihttps://hdl.handle.net/10468/18779
dc.identifier.volume47
dc.language.isoen
dc.publisherSpringer-Verlag Italia s.r.l.
dc.relation.urihttps://www.scopus.com/pages/publications/105033433988
dc.rights© 2026, the Authors.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectDUSP1
dc.subjectMicroglia/macrophages
dc.subjectMultiple sclerosis
dc.subjectWhite matter
dc.subject[APCMicrobiome]
dc.subject[Medicine]
dc.titleDownregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosisen
dc.typeArticle (peer-reviewed)
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