Elucidating the microbiome of Irish athletes

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dc.availability.bitstreamembargoed
dc.check.chapterOfThesisChapters 5 (pages 205-256) and 6 (pages 257-420) for a period of 3 years.en
dc.check.date2026-03-20
dc.contributor.advisorCotter, Paulen
dc.contributor.advisorO'Sullivan, Orlaen
dc.contributor.advisorJoyce, Susanen
dc.contributor.advisorGahan, Cormac G.en
dc.contributor.authorO'Donovan, Ciara M.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2020-05-13T09:59:53Z
dc.date.available2020-05-13T09:59:53Z
dc.date.issued2020-02
dc.date.submitted2020-02
dc.description.abstractExercise has been established as a factor that has a beneficial impact on several body systems, including the prevention and treatment of obesity, and alleviation of symptoms affecting the cardiovascular system. A variation in the gut microbiome composition and functionality of athletes relative to that of the general population has been identified. Numerous factors have the potential to alter the gut microbiome of athletes, including type of sport, travel for competition, and training intensity. This thesis explores these factors, while also assessing how they impact on microbial and host metabolism. After reviewing several aspects of the topic in chapters 1 and 2, in chapter 3, we investigate the impact of travel on the athlete gut microbiome using 16S rRNA and shotgun metagenomic sequencing approaches. In chapter 4, we evaluate the differences in the gut microbiome and metabolome between athletes participating in different types of sports. Chapter 5 focuses on profiling the bile and fatty acid content and bile salt hydrolase potential of athletes and controls and, finally, in chapter 6, we employ shotgun metagenomic sequencing to analyse the composition and functional potential of the gut microbiome in an active cohort to determine the impact of activity level and fitness. Overall, this thesis explores the factors that influence an athlete’s gut microbiome, and indicates a role for travel as well as sports type and activity level on gut microbiome composition, functional potential, and metabolism.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Donovan, C. M. 2020. Elucidating the microbiome of Irish athletes. PhD Thesis, University College Cork.en
dc.identifier.endpage433en
dc.identifier.urihttps://hdl.handle.net/10468/9942
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2160/IE/Investigating the impact of high intensity exercise and/or protein intake levels on gut microbial diversity./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/11/PI/1137/IE/Obesibiotics/en
dc.rights© 2020, Ciara M. O'Donovan.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectExerciseen
dc.subjectAthleteen
dc.subjectGut microbiomeen
dc.subjectMetabolomeen
dc.titleElucidating the microbiome of Irish athletesen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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