Silicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurement

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dc.contributor.authorLi, Yanlu
dc.contributor.authorMarais, Louise
dc.contributor.authorKhettab, Hakim
dc.contributor.authorQuan, Zhiheng
dc.contributor.authorAasmul, Soren
dc.contributor.authorLeinders, Rob
dc.contributor.authorSchüler, Ralf
dc.contributor.authorMorrissey, Padraic E.
dc.contributor.authorGreenwald, Stephen
dc.contributor.authorSegers, Patrick
dc.contributor.authorVanslembrouck, Michael
dc.contributor.authorBruno, Rosa M.
dc.contributor.authorBoutouyrie, Pierre
dc.contributor.authorO'Brien, Peter
dc.contributor.authorde Melis, Mirko
dc.contributor.authorBaets, Roel
dc.contributor.funderHorizon 2020en
dc.date.accessioned2021-02-22T11:45:11Z
dc.date.available2021-02-22T11:45:11Z
dc.date.issued2020-06-22
dc.date.updated2020-12-14T14:49:14Z
dc.description.abstractPulse wave velocity (PWV) is a reference measure for aortic stiffness, itself an important biomarker of cardiovascular risk. To enable low-cost and easy-to-use PWV measurement devices that can be used in routine clinical practice, we have designed several handheld PWV sensors using miniaturized laser Doppler vibrometer (LDV) arrays in a silicon photonics platform. The LDV-based PWV sensor design and the signal processing protocol to obtain pulse transit time (PTT) and carotid-femoral PWV in a feasibility study in humans, are described in this paper. Compared with a commercial reference PWV measurement system, measuring arterial pressure waveforms by applanation tonometry, LDV-based displacement signals resulted in more complex signals. However, we have shown that it is possible to identify reliable fiducial points for PTT calculation using the maximum of the 2nd derivative algorithm in LDV-based signals, comparable to those obtained by the reference technique, applanation tonometry.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLi, Y., Marais, L., Khettab, H., Quan, Z., Aasmul, S., Leinders, R., Schüler, R., Morrissey, P. E., Greenwald, S., Segers, P., Vanslembrouck, M., Bruno, R. M., Boutouyrie, P., O'Brien, P., de Melis, M. and Baets, R. (2020) 'Silicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurement', Biomedical Optics Express, 11(7), pp. 3913-3926. doi: 10.1364/BOE.394921en
dc.identifier.doi10.1364/BOE.394921en
dc.identifier.eissn2156-7085
dc.identifier.endpage3926en
dc.identifier.issued7en
dc.identifier.journaltitleBiomedical Optics Expressen
dc.identifier.startpage3913en
dc.identifier.urihttps://hdl.handle.net/10468/11081
dc.identifier.volume11en
dc.language.isoenen
dc.publisherOptical Society of Americaen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/644798/EU/Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics/CARDISen
dc.rights© 2021, Optical Society of America under the terms of the OSA Open Access Publishing Agreement.en
dc.subjectPulse wave velocityen
dc.subjectPWVen
dc.subjectAortic stiffnessen
dc.subjectCardiovascular risken
dc.subjectClinical practiceen
dc.subjectHandheld PWV sensoren
dc.subjectLaser Doppler vibrometeren
dc.subjectLDVen
dc.subjectSilicon photonics platformen
dc.subject~Tyndall National Institute - Journal Articles~en
dc.titleSilicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurementen
dc.typeArticle (peer-reviewed)en
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