Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis

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dc.check.date2019-11-14
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorBjornevik, Kjetil
dc.contributor.authorO'Reilly, Éilis J.
dc.contributor.authorBerry, James D.
dc.contributor.authorClish, Clary B.
dc.contributor.authorJeanfavre, Sarah
dc.contributor.authorKato, Ikuko
dc.contributor.authorKolonel, Laurence N.
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorMcCullough, Marjorie L.
dc.contributor.authorPaganoni, Sabrina
dc.contributor.authorSchwarzschild, Michael A.
dc.contributor.authorTalbott, Evelyn O.
dc.contributor.authorWallace, Robert B.
dc.contributor.authorZhang, Zhongli
dc.contributor.authorManson, JoAnn E.
dc.contributor.authorAscherio, Alberto
dc.contributor.funderNational Institute of Neurological Disorders and Strokeen
dc.contributor.funderNational Institutes of Healthen
dc.contributor.funderAmerican Cancer Societyen
dc.contributor.funderNational Heart, Lung, and Blood Instituteen
dc.contributor.funderU.S. Department of Health and Human Servicesen
dc.date.accessioned2019-05-28T10:19:42Z
dc.date.available2019-05-28T10:19:42Z
dc.date.issued2018-11-14
dc.date.updated2019-05-22T10:59:47Z
dc.description.abstractObjective: To assess whether prediagnostic levels of plasma branched-chain amino acids (BCAAs) are associated with amyotrophic lateral sclerosis (ALS) risk. Methods: We included participants from 5 large cohort studies—The Nurses' Health Study, the Health Professionals Follow-up Study, the Cancer Prevention Study II Nutrition, the Multiethnic Cohort Study, and the Women's Health Initiative—and identified 275 individuals who developed ALS during follow-up. Two controls were randomly selected for each case, matched on cohort, age, sex, fasting status, and time of blood draw. We measured metabolites using liquid chromatography–mass spectrometry and used conditional logistic regression to estimate rate ratios (RRs) and 95% confidence intervals (CIs) for the association of individual BCAAs with ALS risk. Results: None of the 3 BCAAs was associated with a higher ALS risk. The risk estimates were similar for leucine (RR top vs bottom quartile: 0.87, 95% CI 0.57–1.33), isoleucine (RR top vs bottom quartile: 0.81, 95% CI 0.52–1.24), and valine (RR top vs bottom quartile: 0.80, 95% CI 0.52–1.23) in a multivariable analysis adjusted for body mass index, smoking, level of education, and physical activity. The estimates did not vary significantly by sex, fasting status, or time interval between blood draw and disease onset. Conclusion: The results from this study do not support the hypothesis that BCAAs are risk factors for ALS.en
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke (R01 NS045893); National Institutes of Health (Grants UM1 CA186107; R01 CA49449; UM1 CA167552; U01 CA164973); U.S. Department of Health and Human Services (contracts HHSN268201600018C; HHSN268201600001C; HHSN268201600002C)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBjornevik, K., O'Reilly, É. J., Berry, J. D., Clish, C. B., Jeanfavre, S., Kato, I., Kolonel, L. N., Le Marchand, L., McCullough, M. L., Paganoni, S., Schwarzschild, M. A., Talbott, E. O., Wallace, R. B., Zhang, Z., Manson, J. E. and Ascherio, A. (2019) 'Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis', Neurology, 92(18), pp. 2081-2088. doi: 10.1212/WNL.0000000000006669en
dc.identifier.doi10.1212/WNL.0000000000006669en
dc.identifier.eissn1526-632X
dc.identifier.endpage2088en
dc.identifier.issn0028-3878
dc.identifier.issued18en
dc.identifier.journaltitleNeurologyen
dc.identifier.startpage2081en
dc.identifier.urihttps://hdl.handle.net/10468/7987
dc.identifier.volume92en
dc.language.isoenen
dc.publisherAmerican Academy of Neurologyen
dc.relation.urihttps://n.neurology.org/content/neurology/92/18/e2081.full.pdf
dc.rights© 2018, American Academy of Neurology. All rights reserved.en
dc.subjectALSen
dc.subjectPlasmaen
dc.subjectBranched-chain amino acidsen
dc.subjectBCAAsen
dc.subjectAmyotrophic lateral sclerosisen
dc.titlePrediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosisen
dc.typeArticle (peer-reviewed)en
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