Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection

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dc.contributor.authorVazquez, Patricia
dc.contributor.authorHerzog, Grégoire
dc.contributor.authorO'Mahony, Conor
dc.contributor.authorO'Brien, Joseph
dc.contributor.authorScully, James
dc.contributor.authorBlake, Alan
dc.contributor.authorÓ Mathúna, S. Cian
dc.contributor.authorGalvin, Paul
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-05-22T14:56:48Z
dc.date.available2019-05-22T14:56:48Z
dc.date.issued2014-05-02
dc.date.updated2019-05-22T14:46:23Z
dc.description.abstractThis report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationVazquez, P., Herzog, G., O’Mahony, C., O’Brien, J., Scully, J., Blake, A., O’Mathuna, C. and Galvin, P. (2014) 'Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection', Sensors and Actuators B: Chemical, 201, pp. 572-578. doi: 10.1016/j.snb.2014.04.080en
dc.identifier.doi10.1016/j.snb.2014.04.080en
dc.identifier.endpage578en
dc.identifier.issn0925-4005
dc.identifier.journaltitleSensors and Actuators B: Chemicalen
dc.identifier.startpage572en
dc.identifier.urihttps://hdl.handle.net/10468/7969
dc.identifier.volume201en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/I1147/IE/CSET CLARITY: Bringing Information to Life/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2289/IE/INSIGHT - Irelands Big Data and Analytics Research Centre/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/10/CE/B1821/IE/CSET BDI: Biomedical Diagnostics Institute/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0925400514004912
dc.rights© 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicroneedlesen
dc.subjectMicro-interfacesen
dc.subjectITIESen
dc.subjectMinimally invasiveen
dc.subjectStripping voltammetryen
dc.subjectβ-Blocker drugen
dc.titleMicroscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detectionen
dc.typeArticle (peer-reviewed)en
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