Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection
dc.contributor.author | Vazquez, Patricia | |
dc.contributor.author | Herzog, Grégoire | |
dc.contributor.author | O'Mahony, Conor | |
dc.contributor.author | O'Brien, Joseph | |
dc.contributor.author | Scully, James | |
dc.contributor.author | Blake, Alan | |
dc.contributor.author | Ó Mathúna, S. Cian | |
dc.contributor.author | Galvin, Paul | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.date.accessioned | 2019-05-22T14:56:48Z | |
dc.date.available | 2019-05-22T14:56:48Z | |
dc.date.issued | 2014-05-02 | |
dc.date.updated | 2019-05-22T14:46:23Z | |
dc.description.abstract | This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Vazquez, P., Herzog, G., O’Mahony, C., O’Brien, J., Scully, J., Blake, A., O’Mathuna, C. and Galvin, P. (2014) 'Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection', Sensors and Actuators B: Chemical, 201, pp. 572-578. doi: 10.1016/j.snb.2014.04.080 | en |
dc.identifier.doi | 10.1016/j.snb.2014.04.080 | en |
dc.identifier.endpage | 578 | en |
dc.identifier.issn | 0925-4005 | |
dc.identifier.journaltitle | Sensors and Actuators B: Chemical | en |
dc.identifier.startpage | 572 | en |
dc.identifier.uri | https://hdl.handle.net/10468/7969 | |
dc.identifier.volume | 201 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/I1147/IE/CSET CLARITY: Bringing Information to Life/ | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2289/IE/INSIGHT - Irelands Big Data and Analytics Research Centre/ | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/10/CE/B1821/IE/CSET BDI: Biomedical Diagnostics Institute/ | en |
dc.relation.uri | http://www.sciencedirect.com/science/article/pii/S0925400514004912 | |
dc.rights | © 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Microneedles | en |
dc.subject | Micro-interfaces | en |
dc.subject | ITIES | en |
dc.subject | Minimally invasive | en |
dc.subject | Stripping voltammetry | en |
dc.subject | β-Blocker drug | en |
dc.title | Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection | en |
dc.type | Article (peer-reviewed) | en |