Modelling the tumour microenvironment and reversible and irreversible chemotherapy resistance

Simple item page
dc.check.date2026-05-31
dc.contributor.advisorWieczorek, Sebastian
dc.contributor.advisorAlkhayuon, Hassan
dc.contributor.advisorMulchrone, Kieran F.
dc.contributor.authorQuinlan, Thomasen
dc.contributor.funderUniversity College Cork
dc.date.accessioned2025-02-12T13:40:21Z
dc.date.available2025-02-12T13:40:21Z
dc.date.issued2024
dc.date.submitted2024
dc.description.abstractThe tumour microenvironment (TME) comprises various cell types, including cancer cells, immune cells, and stromal cells, which all engage in complex, dynamical interactions. Understanding these interactions, particularly their role in promoting cancer growth and the emergence of drug resistance, is crucial for developing effective treatment strategies. This project constructs a comprehensive mathematical model of the TME that incorporates the effects of chemotherapy. We systematically derive a series of process-based equations to describe the tripartite interactions between cancer cells, immune cells and stromal cells within the TME, as well as their response to chemotherapy. Throughout the model development, we analyse sub-models to ensure we capture key qualitative behaviours. Finally, we conduct a qualitative study by simulating our model under various hypothetical TME scenarios and different chemotherapy dosing schedules. Our simulations demonstrate how variations in stromal activity and treatment regimens can lead to diverse patient outcomes, highlighting the need for personalised treatment strategies.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationQuinlan, T. 2024. Modelling the tumour microenvironment and reversible and irreversible chemotherapy resistance. MRes Thesis, University College Cork.
dc.identifier.endpage126
dc.identifier.urihttps://hdl.handle.net/10468/17027
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectUniversity College Cork (School of Mathematical Sciences, Boole Fellowship)
dc.rights© 2024, Thomas Quinlan.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMathematical modelling
dc.subjectCancer
dc.subjectStroma
dc.subjectImmune system
dc.subjectChemotherapy
dc.subjectDrug resistance
dc.subjectDynamical systems
dc.subjectMathematical biology
dc.subjectMathematical oncology
dc.subjectTumour microenvironment
dc.subjectTreatment scheduling
dc.titleModelling the tumour microenvironment and reversible and irreversible chemotherapy resistance
dc.typeMasters thesis (Research)en
dc.type.qualificationlevelMastersen
dc.type.qualificationnameMSc - Master of Scienceen
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
QuinlanT_MRes2024.pdf
Size:
4.48 MB
Format:
Adobe Portable Document Format
Description:
Full Text E-thesis
Thumbnail Image
Name:
3. 119353211 - Thomas Francis Quinlan - Submission for examination form.pdf
Size:
435.13 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
5.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Theses
College of Science, Engineering and Food Science - Masters by Research Theses
Mathematical Sciences - Masters by Research Theses