Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudis

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dc.contributor.authorKonczal, Mateusz
dc.contributor.authorPrzesmycka, Karolina J.
dc.contributor.authorMohammed, Ryan S.
dc.contributor.authorPhillips, Karl P.
dc.contributor.authorCamara, Francisco
dc.contributor.authorChmielewski, Sebastian
dc.contributor.authorHahn, Christoph
dc.contributor.authorGuigo, Roderic
dc.contributor.authorCable, Jo
dc.contributor.authorRadwan, Jacek
dc.contributor.funderNarodowe Centrum Naukien
dc.contributor.funderSpanish National Bioinformatics Instituteen
dc.contributor.funderMinisterio de Economía y Competitividaden
dc.date.accessioned2020-04-14T12:12:56Z
dc.date.available2020-04-14T12:12:56Z
dc.date.issued2020-03-28
dc.date.updated2020-04-03T13:02:02Z
dc.description.abstractDetermining the molecular basis of parasite adaptation to its host is an important component in understanding host-parasite coevolution and the epidemiology of parasitic infections. Here, we investigate short- and long-term adaptive evolution in the eukaryotic parasite, Gyrodactylus bullatarudis, infecting Caribbean guppies (Poecilia reticulata), by comparing the reference genome of Tobagonian G. bullatarudis with other Platyhelminthes, and by analyzing resequenced samples from local Trinidadian populations. At the macroevolutionary timescale, we observed duplication of G-protein and serine proteases genes, which are likely important in host-parasite arms races. Serine protease also showed strong evidence of ongoing, diversifying selection at the microevolutionary timescale. Furthermore, our analyses revealed that a hybridization event, involving two divergent genomes, followed by recombination has dramatically affected the genetic composition of Trinidadian populations. The recombinant genotypes invaded Trinidad and replaced local parasites in all populations. We localized more than 300 genes in regions fixed in local populations for variants of different origin, possibly due to diversifying selection pressure from local host populations. In addition, around 70 genes were localized in regions identified as heterozygous in some, but not all, individuals. This pattern is consistent with a very recent spread of recombinant parasites. Overall, our results are consistent with the notion that recombination between divergent genomes can result in particularly successful parasites.en
dc.description.sponsorshipNarodowe Centrum Nauki (Fuga Grant UMO-509-2016/20/S/NZ8/00208); Spanish National Bioinformatics Institute (Project PT13/0001/0021 (ISCIII -FEDER)); Spanish Ministry of Economy and Competitiveness (Centro de Excelencia Severo Ochoa 2013-2017’, SEV-2012-0208)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKonczal, M., Przesmycka, K. J., Mohammed, R. S., Phillips, K. P., Camara, F., Chmielewski, S., Hahn, C., Guigo, R., Cable, J. and Radwan, J. (2020) 'Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudis', Molecular Ecology. doi: 10.1111/mec.15421en
dc.identifier.doi10.1111/mec.15421en
dc.identifier.eissn1365-294X
dc.identifier.issn1365-294X
dc.identifier.journaltitleMolecular Ecologyen
dc.identifier.urihttps://hdl.handle.net/10468/9824
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.rights© 2020, John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Konczal, M., Przesmycka, K. J., Mohammed, R. S., Phillips, K. P., Camara, F., Chmielewski, S., Hahn, C., Guigo, R., Cable, J. and Radwan, J. (2020) 'Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudis', Molecular Ecology, doi: 10.1111/mec.15421, which has been published in final form at https://doi.org/10.1111/mec.15421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectAdaptive evolutionen
dc.subjectAdmixture hybridsen
dc.subjectParasiteen
dc.subjectRecombination reference genomeen
dc.titleGene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite, Gyrodactylus bullatarudisen
dc.typeArticle (peer-reviewed)en
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