Microbiome: a key regulator of body-brain interactions

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dc.check.date2026-05-30en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorO’Riordan, Kenneth J.en
dc.contributor.authorAburto, Maria R.en
dc.contributor.authorNagpal, Jatinen
dc.contributor.authorClarke, Gerarden
dc.contributor.authorCryan, John F.en
dc.contributor.editorTropea, Danielaen
dc.contributor.editorGiacometti, Emanuelaen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Research Councilen
dc.contributor.funderHORIZON EUROPE European Research Councilen
dc.date.accessioned2025-08-12T11:20:18Z
dc.date.available2025-08-12T11:20:18Z
dc.date.issued2025-05-30en
dc.description.abstractThe gut microbiota, consisting of trillions of microorganisms, plays a critical role in regulating host physiology, including metabolism, immune responses, and brain function. This chapter examines the microbiota-gut-brain axis, a multifaceted bidirectional communication system connecting gut microbial activity with central nervous system processes through immune pathways, metabolic byproducts, and neural circuits like the vagus nerve. The evolution of the gut microbiota throughout an individual’s life—from early developmental influences like birth mode and antibiotic use to changes associated with aging and neurodegenerative conditions—highlights its dynamic nature. The chapter reviews experimental approaches and microbiome-based interventions to demonstrate the influence of gut microbiota on neurological conditions such as autism spectrum disorder, anxiety, and Alzheimer’s disease. Finally, it emphasises the importance of advancing microbiome-targeted therapies, integrating emerging technologies, and clinical trials to develop personalised strategies for enhancing brain health through gut microbiome modulation.en
dc.description.sponsorshipIrish Research Council (GOIPD/2019/714)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO’Riordan, K. J., Aburto, M. R., Nagpal, J., Clarke, G. and Cryan, J. F. (2025) 'Microbiome: a key regulator of body-brain interactions', in Tropea, D. and Giacometti, E. (eds.) Brain-Body Connections: Bidirectional Communication Between the Brain and Body Systems, pp.139-203. Advances in Experimental Medicine and Biology, vol 1477. Springer, Cham. https://doi.org/10.1007/978-3-031-89525-8_6en
dc.identifier.doi10.1007/978-3-031-89525-8_6en
dc.identifier.eissn2214-8019en
dc.identifier.endpage203en
dc.identifier.isbn9783031895241en
dc.identifier.isbn9783031895258en
dc.identifier.issn0065-2598en
dc.identifier.journaltitleAdvances in Experimental Medicine and Biologyen
dc.identifier.startpage139en
dc.identifier.urihttps://hdl.handle.net/10468/17774
dc.identifier.volume1477en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.ispartofAdvances in Experimental Medicine and Biologyen
dc.relation.ispartofBrain-Body Connections: Bidirectional Communication Between the Brain and Body Systemsen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Pathway Programme::STEM-led/22/PATH-S/10876/IE/The role of early-life microbiome in sculpting stress-social neural circuits in zebrafish./en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/HE::HORIZON-AG/101040951/EU/Radial Glia as Neurodevelopmental Mediators Of Gut Microbiota Signals/RADIOGUTen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Pathway Programme::STEM-led/21/PATH-S/9424/IE/Deciphering the role of early life microbiota in neuro-glia-vascular development and contributions to neurodevelopmental disorders./en
dc.rights© 2025, The Authors, under exclusive license to Springer Nature Switzerland AG. This version of the chapter has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/978-3-031-89525-8_6en
dc.subjectMicrobiota-gut-brain axisen
dc.subjectGut microbiotaen
dc.subjectNeuroinflammationen
dc.subjectShort-chain fatty acids (SCFAs)en
dc.subjectVagus nerveen
dc.subjectBlood-brain barrier (BBB)en
dc.subjectPsychobioticsen
dc.subjectNeurodevelopmenten
dc.titleMicrobiome: a key regulator of body-brain interactionsen
dc.typeBook chapteren
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