Evaluating the impact of general practice pharmacist‐led person‐centred medicines reviews on medicines appropriateness and patient‐reported outcome measures

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dc.contributor.authorKinahan, Clareen
dc.contributor.authorKirke, Ciaraen
dc.contributor.authorO'Hagan, Leonen
dc.contributor.authorMoriarty, Franken
dc.contributor.authorMurphy, Kevin D.en
dc.contributor.authorSahm, Laura J.en
dc.contributor.authorO'Mahony, Cianen
dc.contributor.authorCoyle, Emma J.en
dc.contributor.authorByrne, Stephenen
dc.contributor.authorDalton, Kieranen
dc.contributor.funderInterregen
dc.date.accessioned2025-07-24T11:09:54Z
dc.date.available2025-07-24T11:09:54Z
dc.date.issued2025-02-10en
dc.description.abstractAim: The aim of this study was to investigate the impact of pharmacist-led person-centred medicines reviews in general practices on medicines appropriateness, polypharmacy indicators (high-risk prescribing markers), and patient-reported outcome measures (PROMs). Methods: Four pharmacists conducted person-centred medicines reviews in ten general practices between January 2021 and December 2022 for patients with hyperpolypharmacy (prescribed ≥10 regular medicines) and/or at high risk of medicines-related harm. Prescribing recommendations were provided to the general practitioner and followed up with patients and/or healthcare professionals. In this single arm study, pre and post intervention: (1) polypharmacy indicators were documented, and for a sample of patients, the (2) Person-Centred Medication Appropriateness Index (PC-MAI) scores and (3) PROMs were gathered. Results: Of the 1471 included patients, the mean age was 76 years, 88.4% had hyperpolypharmacy, whilst the mean number of medicines was 13.8 pre and 12.3 post review. Of the 1056 polypharmacy indicator occurrences identified, 70.7% were resolved post review. Of the 194 patients with pre-review and post-review PC-MAI scores, 99% had a reduction; the mean reduction was 17.3 (95% confidence interval [CI] 15.8–18.8, P < .0001) per patient and 1.2 (95% CI 1.0–1.3, P < .0001) per medicine. PROMs were collected for 179 patients; 87.7% reported the review helped their medicines understanding, 63.1% their experience of side effects, 36.9% their ability to take medicines correctly, and 30.5% the impact of medicines on their daily activities. Conclusions: General practice pharmacist-led person-centred medicines reviews for patients with hyperpolypharmacy and/or at high risk of medicines-related harm delivered substantial improvements in medicines appropriateness and patient-reported outcomes, thus providing evidence to support their wider implementation.en
dc.description.sponsorshipInterreg (iSIMPATHY project IVA 5081)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKinahan, C., Kirke, C., O'Hagan, L., Moriarty, F., Murphy, K. D., Sahm, L. J., O'Mahony, C., Coyle, E. J., Byrne, S. and Dalton, K. (2025) 'Evaluating the impact of general practice pharmacist‐led person‐centred medicines reviews on medicines appropriateness and patient‐reported outcome measures', British Journal of Clinical Pharmacology, 91(6), pp.1802-1820. https://doi.org/10.1111/bcp.16372en
dc.identifier.doi10.1111/bcp.16372en
dc.identifier.eissn1365-2125en
dc.identifier.endpage1820en
dc.identifier.issn0306-5251en
dc.identifier.issued6en
dc.identifier.journaltitleBritish Journal of Clinical Pharmacologyen
dc.identifier.startpage1802en
dc.identifier.urihttps://hdl.handle.net/10468/17753
dc.identifier.volume91en
dc.language.isoenen
dc.publisherBritish Pharmacological Societyen
dc.relation.ispartofBritish Journal of Clinical Pharmacologyen
dc.rights© 2025, the Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in anymedium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectGeneral practiceen
dc.subjectMedication reviewen
dc.subjectPatient-reported outcome measuresen
dc.subjectPharmacisten
dc.subjectPolypharmacyen
dc.subject~Pharmacy - Journal Articles~en
dc.titleEvaluating the impact of general practice pharmacist‐led person‐centred medicines reviews on medicines appropriateness and patient‐reported outcome measuresen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue6en
oaire.citation.volume91en
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