Efficacy of non-pharmacological interventions to treat malnutrition in older persons: a systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project

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dc.check.date2019-11-02
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorCorrea-PĂ©rez, Andrea
dc.contributor.authorAbraha, Iosief
dc.contributor.authorCherubini, Antonio
dc.contributor.authorCollinson, Avril
dc.contributor.authorDardevet, Dominique
dc.contributor.authorde Groot, Lisette C. P. G. M.
dc.contributor.authorde van der Schueren, Marian A. E.
dc.contributor.authorHebestreit, Antje
dc.contributor.authorHickson, Mary
dc.contributor.authorJaramillo-Hidalgo, Javier
dc.contributor.authorLozano-Montoya, Isabel
dc.contributor.authorO'Mahony, Denis
dc.contributor.authorSoiza, Roy L.
dc.contributor.authorVisser, Marjolein
dc.contributor.authorVolkert, Dorothee
dc.contributor.authorWolters, Maike
dc.contributor.authorCruz Jentoft, Alfonso J.
dc.contributor.funderBundesministerium für Ernährung und Landwirtschaftde
dc.contributor.funderZonMwnl
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderEcole Supérieure d’Agricultures, Francefr
dc.date.accessioned2018-12-10T18:04:54Z
dc.date.available2018-12-10T18:04:54Z
dc.date.issued2018-11-02
dc.date.updated2018-12-04T09:47:10Z
dc.description.abstractIntroduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. Results: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. Conclusions: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCorrea-PĂ©rez, A., Abraha, I., Cherubini, A., Collinson, A., Dardevet, D., de Groot, L. C. P. G. M., de van der Schueren, M. A. E., Hebestreit, A., Hickson, M., Jaramillo-Hidalgo, J., Lozano-Montoya, I., O'Mahony, D., Soiza, R. L., Visser, M., Volkert, D., Wolters, M. and Cruz Jentoft, A. J. (2018) 'Efficacy of non-pharmacological interventions to treat malnutrition in older persons: a systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project', Ageing Research Reviews, 49, pp. 27-48. doi:10.1016/j.arr.2018.10.011en
dc.identifier.doi10.1016/j.arr.2018.10.011
dc.identifier.endpage48en
dc.identifier.issn1568-1637
dc.identifier.journaltitleAgeing Research Reviewsen
dc.identifier.startpage27en
dc.identifier.urihttps://hdl.handle.net/10468/7196
dc.identifier.volume49en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/305930/EU/Development and clinical trials of a new Software ENgine for the Assessment & Optimization of drug and non-drug Therapy in Older peRsons/SENATORen
dc.rights© 2018, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectProtein energy malnutritionen
dc.subjectElderlyen
dc.subjectDietary supplementationen
dc.subjectReviewen
dc.subjectSystematicen
dc.titleEfficacy of non-pharmacological interventions to treat malnutrition in older persons: a systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub projecten
dc.typeArticle (peer-reviewed)en
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