Detection of ultra-low protein concentrations with the simplest possible field effect transistor

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dc.contributor.authorGeorgiev, Yordan M.
dc.contributor.authorPetkov, Nikolay
dc.contributor.authorYu, Ran
dc.contributor.authorNightingale, Adrian M.
dc.contributor.authorBuitrago, Elizabeth
dc.contributor.authorLotty, Olan
dc.contributor.authorDeMello, John C.
dc.contributor.authorIonesco, Adrian M.
dc.contributor.authorHolmes, Justin D.
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-05-20T09:13:13Z
dc.date.available2019-05-20T09:13:13Z
dc.date.issued2019-05-08
dc.date.updated2019-05-16T09:38:11Z
dc.description.abstractSilicon nanowire (Si NW) sensors have attracted great attention due to their ability to provide fast, low-cost, label-free, real-time detection of chemical and biological species. Usually configured as field effect transistors (FETs), they have already demonstrated remarkable sensitivity with high selectivity (through appropriate functionalisation) towards a large number of analytes in both liquid and gas phases. Despite these excellent results, Si NW FET sensors have not yet been successfully employed to detect single molecules of either a chemical or biological target species. Here we show that sensors based on silicon junctionless nanowire transistors (JNTs), the simplest possible transistors, are capable of detecting the protein streptavidin at a concentration as low as 580 zM closely approaching the single molecule level. This ultrahigh detection sensitivity is due to the intrinsic advantages of junctionless devices over conventional FETs. Apart from their superior functionality, JNTs are much easier to fabricate by standard microelectronic processes than transistors containing p–n junctions. The ability of JNT sensors to detect ultra-low concentrations (in the zeptomolar range) of target species, and their potential for low-cost mass production, will permit their deployment in numerous environments, including life sciences, biotechnology, medicine, pharmacology, product safety, environmental monitoring and security.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid324001en
dc.identifier.citationGeorgiev, Y. M., Petkov, N., Yu, R., Nightingale, A. M., Buitrago, E., Lotty, O., deMello, J. C., Ionescu, A. and Holmes, J. D. (2019) 'Detection of ultra-low protein concentrations with the simplest possible field effect transistor', Nanotechnology, 30 (32), 324001 (8 pp). doi: 10.1088/1361-6528/ab192cen
dc.identifier.doi10.1088/1361-6528/ab192cen
dc.identifier.endpage8en
dc.identifier.issn1361-6528
dc.identifier.issued32en
dc.identifier.journaltitleNanotechnologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7934
dc.identifier.volume30en
dc.language.isoenen
dc.publisherIOP Publishingen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::ICT/257856/EU/Semiconducting Nanowire Platform for Autonomous Sensors/SINAPSen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/09/IN.1/I2602/IE/Novel Nanowire Structures for Devices/en
dc.relation.urihttps://iopscience.iop.org/article/10.1088/1361-6528/ab192c/meta
dc.rights© 2019 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Nanotechnology The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-6528/ab192c .en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectSi nanowire biosensoren
dc.subjectJunctionless nanowire transistoren
dc.subjectUltrahigh detection sensitivityen
dc.subjectProteinen
dc.subjectStreptavidinen
dc.subjectSingle-molecule detectionen
dc.titleDetection of ultra-low protein concentrations with the simplest possible field effect transistoren
dc.typeArticle (peer-reviewed)en
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