Validity of the Spanish version of the quick mild cognitive impairment screen (Qmci-S)
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Accepted Version
Date
2025-12-05
Authors
Orfila, Francesc
Leiva-Bañuelos, Nuria
Vázquez-Ibar, Olga
Molloy, D. William
O'Caoimh, Rónán
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE Publications
Published Version
Abstract
Background
Accurate, short, cognitive screening instruments are important for identifying mild cognitive impairment (MCI) and dementia including Alzheimer's disease. The Quick Mild Cognitive Impairment (Qmci) screen, given its brevity, may be useful in this setting but it has not been validated in Spanish.
Objective
To compare the diagnostic accuracy of the Spanish version (Qmci-S) to the Montreal Cognitive Assessment (MoCA).
Methods
Patients aged ≥55 years were recruited from six Primary Care Teams in Barcelona, Spain, between 2018–2019. Dementia, MCI, and normal cognition (NC) were classified following neuropsychological testing, independent of the Qmci-S and MoCA scores. Diagnostic accuracy was determined by the area under receiver operating characteristic curves (AUC), adjusted for age and education.
Results
In total, 337 patients were included, mean 77.9 years, standard deviation (SD) ± 6.9. Most were female (57.3%). The intraclass correlation coefficient for the Qmci-S was excellent (0.98). The Qmci-S had good to excellent diagnostic accuracy for separating NC from MCI and dementia (AUC 0.91) and was statistically greater than the MoCA (AUC 0.86), p = 0.029. Accuracy was similar for differentiating NC from MCI and MCI from dementia. The Qmci-S had a shorter administer time, mean 8.6 (±3.2) versus 12.75 (SD ±5.5) minutes, respectively, p < 0.001.
Conclusions
The newly developed Qmci-S screen showed excellent criterion, construct and concurrent validity versus the widely used MoCA and had statistically similar, good to excellent, diagnostic accuracy for cognitive impairment. Its significantly shorter administration time suggests it may be the better screen in a Spanish speaking population in primary care, though further research is required.
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Keywords
Dementia , Mild cognitive impairment , Primary care , Diagnostic test accuracy , Spanish , Cognitive screen
Citation
Orfila, F., Leiva-Bañuelos, N., Vázquez-Ibar, O., Molloy, D.W. and O’Caoimh, R. (2026) ‘Validity of the Spanish version of the quick mild cognitive impairment screen (Q mci -S)’, Journal of Alzheimer’s Disease, 109(2), pp. 853–863. https://doi.org/10.1177/13872877251400791
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Copyright
© 2026, the Authors. Reprinted by permission of SAGE Publications. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Alzheimer’s Disease, © SAGE Publications. To access the final edited and published work see https://doi.org/10.1177/13872877251400791