Advances in the genomics and metabolomics of dairy lactobacilli: A review

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dc.contributor.authorStefanovic, Ewelina
dc.contributor.authorFitzgerald, Gerald F.
dc.contributor.authorMcAuliffe, Olivia
dc.contributor.funderTeagascen
dc.date.accessioned2017-11-10T09:46:01Z
dc.date.available2017-11-10T09:46:01Z
dc.date.issued2016-08-31
dc.date.updated2017-11-06T10:11:00Z
dc.description.abstractThe Lactobacillus genus represents the largest and most diverse genera of all the lactic acid bacteria (LAB), encompassing species with applications in industrial, biotechnological and medical fields. The increasing number of available Lactobacillus genome sequences has allowed understanding of genetic and metabolic potential of this LAB group. Pangenome and core genome studies are available for numerous species, demonstrating the plasticity of the Lactobacillus genomes and providing the evidence of niche adaptability. Advancements in the application of lactobacilli in the dairy industry lie in exploring the genetic background of their commercially important characteristics, such as flavour development potential or resistance to the phage attack. The integration of available genomic and metabolomic data through the generation of genome scale metabolic models has enabled the development of computational models that predict the behaviour of organisms under specific conditions and present a route to metabolic engineering. Lactobacilli are recognised as potential cell factories, confirmed by the successful production of many compounds. In this review, we discuss the current knowledge of genomics, metabolomics and metabolic engineering of the prevalent Lactobacillus species associated with the production of fermented dairy foods. In-depth understanding of their characteristics opens the possibilities for their future knowledge-based applications.en
dc.description.sponsorshipTeagasc (Walsh Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationStefanovic, E., Fitzgerald, G. and McAuliffe, O. (2016) 'Advances in the genomics and metabolomics of dairy lactobacilli: A review', Food Microbiology, 61, pp. 33-49. doi:10.1016/j.fm.2016.08.009en
dc.identifier.doi10.1016/j.fm.2016.08.009
dc.identifier.endpage49en
dc.identifier.issn0740-0020
dc.identifier.journaltitleFood Microbiologyen
dc.identifier.startpage33en
dc.identifier.urihttps://hdl.handle.net/10468/5004
dc.identifier.volume61en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.rights© 2016, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDairyen
dc.subjectGenomicen
dc.subjectMetabolic engineeringen
dc.titleAdvances in the genomics and metabolomics of dairy lactobacilli: A reviewen
dc.typeReviewen
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