Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin

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dc.contributor.authorLeone, Mara
dc.contributor.authorVan Oorschot, Bart H.
dc.contributor.authorNejadnik, M. Reza
dc.contributor.authorBocchino, Andrea
dc.contributor.authorRosato, Matteo
dc.contributor.authorKersten, Gideon
dc.contributor.authorO'Mahony, Conor
dc.contributor.authorBouwstra, Joke
dc.contributor.authorVan der Maaden, Koen
dc.date.accessioned2019-09-04T08:19:40Z
dc.date.available2019-09-04T08:19:40Z
dc.date.issued2018-11-01
dc.description.abstractMicroneedle technologies have been developed for dermal drug and vaccine delivery, including hollow-, solid-, coated-, and dissolving microneedles. Microneedles have been made in many different geometries and of many different materials, all of which may influence their skin-penetrating ability. To ensure reproducible and effective drug and vaccine delivery via microneedles, the optimal insertion parameters should be known. Therefore, a digitally-controlled microneedle applicator was developed to insert microneedles into the skin via impact insertion (velocity) or via pressing force insertion. Six microneedle arrays with different geometries and/or materials were applied onto ex vivo human skin with varying velocities or pressing forces. Penetration efficiency and delivered antigen dose into the skin after application of microneedles were determined. In general, microneedles pierced the skin more efficiently when applied by impact application as compared to application via pressing force. However, the angle of application of the applicator on the skin can affect the velocity of the impact, influencing the penetration efficiency of microneedles. Regarding the antigen delivery into the skin, the delivered dose was increasing by increasing the velocity or pressure, and thus, increasing the penetration efficiency. These data demonstrate that an applicator is an important tool to determine optimal application conditions with ex vivo human skin.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid211en
dc.identifier.citationLeone, M., van Oorschot, B., Nejadnik, M., Bocchino, A., Rosato, M., Kersten, G., O’Mahony, C., Bouwstra, J. and van der Maaden, K., 2018. Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin. Pharmaceutics, 10(4), (211). DOI:10.3390/pharmaceutics10040211en
dc.identifier.doi10.3390/pharmaceutics10040211en
dc.identifier.eissn1999-4923
dc.identifier.endpage18en
dc.identifier.issued4en
dc.identifier.journaltitlePharmaceuticsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8445
dc.identifier.volume10en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttps://www.mdpi.com/1999-4923/10/4/211
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerlanden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicroneedle arraysen
dc.subjectImpact applicatoren
dc.subjectPressing force applicatoren
dc.subjectSkin penetrationen
dc.subject(Trans)dermal drug/vaccine deliveryen
dc.titleUniversal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skinen
dc.typeArticle (peer-reviewed)en
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