Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study

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dc.contributor.authorGunther, Jacqueline
dc.contributor.authorWalther, Andreas
dc.contributor.authorRippe, Lars
dc.contributor.authorKröll, Stefan
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderKnut och Alice Wallenbergs Stiftelse
dc.date.accessioned2018-09-24T12:37:00Z
dc.date.available2018-09-24T12:37:00Z
dc.date.issued2018
dc.description.abstractBiological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present a theoretical study of a system that combines acousto-optical tomography and slow light spectral filters created using spectral hole burning methods. Using Monte Carlo simulations, a model to obtain the contrast-to-noise ratio (CNR) deep in biological tissue was developed. The simulations show a CNR  >  1 for imaging depths of ∼5  cm in a reflection mode setup, as well as, imaging through ∼12 cm in transmission mode setups. These results are promising and form the basis for future experimental studies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid71209
dc.identifier.citationGunther, J. E., Walther, A., Rippe, L., Kröll, S. and Andersson-Engels, S. (2018) 'Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study', Journal of Biomedical Optics, 23(7), 071209 (8pp). doi: 10.1117/1.JBO.23.7.071209en
dc.identifier.doi10.1117/1.JBO.23.7.071209
dc.identifier.endpage8
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.issued7
dc.identifier.journaltitleJournal of Biomedical Opticsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6882
dc.identifier.volume23
dc.language.isoenen
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/
dc.relation.urihttps://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-07/071209/Deep-tissue-imaging-with-acousto-optical-tomography-and-spectral-hole/10.1117/1.JBO.23.7.071209.full?SSO=1
dc.rights© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOIen
dc.subjectBiological tissueen
dc.subjectOptical imagingen
dc.subjectAcousto-optical tomographyen
dc.subjectDeep tissue imagingen
dc.subjectSlow light spectral filteren
dc.titleDeep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical studyen
dc.typeArticle (peer-reviewed)en
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