Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study

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dc.contributor.authorGunther, Jacqueline
dc.contributor.authorWalther, Andreas
dc.contributor.authorRippe, Lars
dc.contributor.authorKröll, Stefan
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderKnut och Alice Wallenbergs Stiftelse
dc.date.accessioned2018-09-24T12:37:00Z
dc.date.available2018-09-24T12:37:00Z
dc.date.issued2018
dc.description.abstractBiological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present a theoretical study of a system that combines acousto-optical tomography and slow light spectral filters created using spectral hole burning methods. Using Monte Carlo simulations, a model to obtain the contrast-to-noise ratio (CNR) deep in biological tissue was developed. The simulations show a CNR  >  1 for imaging depths of ∼5  cm in a reflection mode setup, as well as, imaging through ∼12 cm in transmission mode setups. These results are promising and form the basis for future experimental studies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid71209
dc.identifier.citationGunther, J. E., Walther, A., Rippe, L., Kröll, S. and Andersson-Engels, S. (2018) 'Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study', Journal of Biomedical Optics, 23(7), 071209 (8pp). doi: 10.1117/1.JBO.23.7.071209en
dc.identifier.doi10.1117/1.JBO.23.7.071209
dc.identifier.endpage8
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.issued7
dc.identifier.journaltitleJournal of Biomedical Opticsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6882
dc.identifier.volume23
dc.language.isoenen
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/
dc.relation.urihttps://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-07/071209/Deep-tissue-imaging-with-acousto-optical-tomography-and-spectral-hole/10.1117/1.JBO.23.7.071209.full?SSO=1
dc.rights© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOIen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiological tissueen
dc.subjectOptical imagingen
dc.subjectAcousto-optical tomographyen
dc.subjectDeep tissue imagingen
dc.subjectSlow light spectral filteren
dc.titleDeep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical studyen
dc.typeArticle (peer-reviewed)en
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