The gut microbiome and atherosclerosis: current knowledge and clinical potential

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dc.contributor.authorAhmad, Adilah
dc.contributor.authorDwivedi, Girish
dc.contributor.authorO'Gara, Fergal
dc.contributor.authorCaparros-Martin, Jose
dc.contributor.authorWard, Natalie
dc.contributor.funderDepartment of Education, Employment and Workplace Relations, Australian Governmenten
dc.contributor.funderUniversity of Western Australiaen
dc.date.accessioned2019-09-06T11:49:01Z
dc.date.available2019-09-06T11:49:01Z
dc.date.issued2019-08-30
dc.date.updated2019-09-06T11:37:52Z
dc.description.abstractCardiovascular disease (CVD) is the leading cause of death worldwide. The human body is populated by a diverse community of microbes, dominated by bacteria, but also including viruses and fungi. The largest and most complex of these communities is located in the gastrointestinal system and with their associated genome, are known as the gut microbiome. Gut microbiome perturbations and related dysbiosis have been implicated in the progression and pathogenesis of CVD, including atherosclerosis, hypertension and heart failure. Although there have been advances in the characterisation and analysis of the gut microbiota and associated bacterial metabolites, the exact mechanisms through which they exert their action is not well understood. This review will focus on the role of the gut microbiome and associated functional components in the development and progression of atherosclerosis. Potential treatments to alter the gut microbiome to prevent or treat atherosclerosis and CVD are also discussed.en
dc.description.sponsorshipDepartment of Education, Employment and Workplace Relations, Australian Government (Research Training Program (RTP) Scholarship); University of Western Australia (Wesfarmers Chair in Cardiology)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAhmad, A., Dwivedi, G., O'Gara, F., Caparros-Martin, J. and Ward, N. (2019) 'The gut microbiome and atherosclerosis: current knowledge and clinical potential', American Journal of Physiology - Heart and Circulatory Physiology. doi: 10.1152/ajpheart.00376.2019en
dc.identifier.doi10.1152/ajpheart.00376.2019en
dc.identifier.eissn1522-1539
dc.identifier.issn0363-6135
dc.identifier.journaltitleAmerican Journal of Physiology - Heart and Circulatory Physiologyen
dc.identifier.urihttps://hdl.handle.net/10468/8462
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.relation.urihttps://www.physiology.org/doi/abs/10.1152/ajpheart.00376.2019
dc.rights© 2019, American Journal of Physiology-Heart and Circulatory Physiology. All rights reserved.en
dc.subjectAtherosclerosisen
dc.subjectCardiovascular diseaseen
dc.subjectDysbiosisen
dc.subjectMicrobiomeen
dc.subjectTMAOen
dc.titleThe gut microbiome and atherosclerosis: current knowledge and clinical potentialen
dc.typeArticle (peer-reviewed)en
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