BC200 (BCYRN1) – The shortest, long, non-coding RNA associated with cancer

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dc.contributor.authorSamson, Julia
dc.contributor.authorCronin, S.
dc.contributor.authorDean, Kellie
dc.contributor.funderIrish Research Council
dc.contributor.funderUniversity College Cork
dc.date.accessioned2018-09-27T12:08:08Z
dc.date.available2018-09-27T12:08:08Z
dc.date.issued2018
dc.description.abstractWith the discovery that the level of RNA synthesis in human cells far exceeds what is required to express protein-coding genes, there has been a concerted scientific effort to identify, catalogue and uncover the biological functions of the non-coding transcriptome. Long, non-coding RNAs (lncRNAs) are a diverse group of RNAs with equally wide-ranging biological roles in the cell. An increasing number of studies have reported alterations in the expression of lncRNAs in various cancers, although unravelling how they contribute specifically to the disease is a bigger challenge. Originally described as a brain-specific, non-coding RNA, BC200 (BCYRN1) is a 200-nucleotide, predominantly cytoplasmic lncRNA that has been linked to neurodegenerative disease and several types of cancer. Here we summarise what is known about BC200, primarily from studies in neuronal systems, before turning to a review of recent work that aims to understand how this lncRNA contributes to cancer initiation, progression and metastasis, along with its possible clinical utility as a biomarker or therapeutic target.en
dc.description.sponsorshipIrish Research Council (Government of Ireland Postgraduate Scholarship (GOIPG/2017/579); University College Cork (Translational Research Access Programme)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSamson, J., Cronin, S. and Dean, K. (2018) 'BC200 (BCYRN1) – The shortest, long, non-coding RNA associated with cancer', Non-coding RNA Research, 3(3), pp. 131-143. doi:10.1016/j.ncrna.2018.05.003en
dc.identifier.doi10.1016/j.ncrna.2018.05.003
dc.identifier.endpage143
dc.identifier.issn2468-0540
dc.identifier.journaltitleNon-coding RNA Researchen
dc.identifier.startpage131
dc.identifier.urihttps://hdl.handle.net/10468/6915
dc.identifier.volume3
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2468054017300537?via%3Dihub
dc.rights© 2018, Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectLong non-coding RNAen
dc.subjectlncRNAen
dc.subjectCanceren
dc.subjectBC200en
dc.subjectBCYRN1en
dc.subjectTranslational regulationen
dc.subjectRNA-protein interactionsen
dc.titleBC200 (BCYRN1) – The shortest, long, non-coding RNA associated with canceren
dc.typeArticle (peer-reviewed)en
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