Synthesis and biological evaluation of novel thionucleosides

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dc.contributor.authorO'Donovan, Fiona P.
dc.contributor.authorO'Leary, Eileen M.
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderIrish Research Councilen
dc.date.accessioned2020-11-23T14:46:03Z
dc.date.available2020-11-23T14:46:03Z
dc.date.issued2020-11-01
dc.date.updated2020-11-23T14:17:26Z
dc.description.abstractThe search for novel nucleosides has been a major research focus in medicinal chemistry for several decades, particularly given their proven track record in the treatment of viral infections and cancer. As bioisosteres of natural nucleosides, thionucleosides are especially attractive targets as they often display improved biological activity. Furthermore, the replacement of oxygen with sulfur may sometimes be accompanied by interesting changes in pharmacological effect. This update covers recent advances in the preparation of novel thionucleosides, grouped by synthetic strategy. The biological properties of the target thionucleosides are also summarised, in addition to any reported structure activity relationships.en
dc.description.sponsorshipIrish Research Council (GOIPG/2014/795)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Donovan, F. P., O'Leary, E. M. and O'Sullivan, T. P. (2020) 'Synthesis and biological evaluation of novel thionucleosides', Current Organic Chemistry, 24(15), pp. 1717-1762. doi: 10.2174/1385272824999200608131955en
dc.identifier.doi10.2174/1385272824999200608131955en
dc.identifier.endpage1762en
dc.identifier.issn1385-2728
dc.identifier.issued15en
dc.identifier.journaltitleCurrent Organic Chemistryen
dc.identifier.startpage1717en
dc.identifier.urihttps://hdl.handle.net/10468/10780
dc.identifier.volume24en
dc.language.isoenen
dc.publisherBentham Science Publishersen
dc.rights© 2020, Bentham Science Publishers. All rights reserved. The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/node/182609/articleen
dc.subjectAnti-viralsen
dc.subjectGlycosylationen
dc.subjectNucleosidesen
dc.subjectSulfuren
dc.subjectSynthesisen
dc.subjectThionucleosidesen
dc.titleSynthesis and biological evaluation of novel thionucleosidesen
dc.typeArticle (peer-reviewed)en
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