Transformation of alkyl and aryl halides into alcohols, thiols and thiophenols

Simple item page
dc.contributor.authorDunne, Oscar
dc.contributor.authorCollins, Emily A.
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderTaighde Éireann – Research Ireland
dc.date.accessioned2026-10-08T14:22:01Z
dc.date.available2026-10-08T14:22:01Z
dc.date.issued2026-07-02
dc.description.abstractAlcohols and thiols are key functionalities which are found in a wide variety of both natural and synthetic bioactive compounds. Additionally, they provide access to an array of other major functional groups, such as aldehydes, ketones, ethers, disulfides and sulfonamides to name but a few. The direct conversion of alkyl and aryl halides constitutes a useful and efficient means of preparing alcohols, thiols and thiophenols. This review summarises the different approaches that have been reported in the literature up to 2026, and includes the application of modern synthetic methods, such as electrochemical and photochemical techniques. In each section, the main features of the different strategies are discussed, while their advantages and disadvantages are captured in high-level summary tables. Accordingly, this review should serve as a useful overview of the current state-of-the-art while also helping to identify gaps for future investigation.en
dc.description.sponsorshipTaighde Éireann – Research Ireland|GOIPG/2024/3375
dc.description.sponsorshipTaighde Éireann – Research Ireland|GOIPG/2021/264
dc.description.versionPublished Version
dc.format.extent62
dc.format.mimetypeapplication/pdfen
dc.identifier.authororcidDunne, Oscar
dc.identifier.authororcidCollins, Emily A.
dc.identifier.authororcidO'Sullivan, Timothy P.
dc.identifier.citationDunne, O, Collins, E A & O'Sullivan, T P 2026, 'Transformation of alkyl and aryl halides into alcohols, thiols and thiophenols', RSC Advances, vol. 16, no. 34, pp. 31442-31503. https://doi.org/10.1039/d6ra00558f
dc.identifier.doi10.1039/d6ra00558f
dc.identifier.endpage31503
dc.identifier.issn2046-2069
dc.identifier.issued34
dc.identifier.startpage31442
dc.identifier.urihttps://hdl.handle.net/10468/19424
dc.identifier.volume16
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.urihttps://www.scopus.com/pages/publications/105043542778
dc.rights© 2026, the Authors. The Royal Society of Chemistry.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectAlcohols
dc.subjectThiols
dc.subjectNatural and synthetic bioactive compounds
dc.subjectThiophenols
dc.subject[Pharmacy]
dc.subject[Chemistry]
dc.titleTransformation of alkyl and aryl halides into alcohols, thiols and thiophenolsen
dc.typeReview
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
d6ra00558f.pdf
Size:
4.19 MB
Format:
Adobe Portable Document Format
Download
Collections
School of Chemistry
School of Pharmacy