The infant gut microbiome as a microbial organ influencing host well-being

Simple item page
dc.contributor.authorTurroni, Francescaen
dc.contributor.authorMilani, Christianen
dc.contributor.authorDuranti, Sabrinaen
dc.contributor.authorLugli, Gabriele A.en
dc.contributor.authorBernasconi, Sergioen
dc.contributor.authorMargolles, Abelardoen
dc.contributor.authorDi Pierro, Francescoen
dc.contributor.authorvan Sinderen, Douween
dc.contributor.authorVentura, Marcoen
dc.contributor.funderHorizon 2020 Framework Programme
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderFondazione Cariparma
dc.date.accessioned2023-05-11T10:16:19Z
dc.date.available2023-05-11T09:48:18Zen
dc.date.available2023-05-11T10:16:19Z
dc.date.issued2020-02en
dc.date.updated2023-05-11T08:48:19Zen
dc.description.abstractInitial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subsequent development of this early gut microbiota is driven and modulated by specific dietary compounds present in human milk that support selective colonization. This represents a very intriguing example of host-microbe co-evolution, where both partners are believed to benefit. In recent years, various publications have focused on dissecting microbial infant gut communities and their interaction with their human host, being a determining factor in host physiology and metabolic activities. Such studies have highlighted a reduction of microbial diversity and/or an aberrant microbiota composition, sometimes referred to as dysbiosis, which may manifest itself during the early stage of life, i.e., in infants, or later stages of life. There are growing experimental data that may explain how the early human gut microbiota affects risk factors related to adult health conditions. This concept has fueled the development of various nutritional strategies, many of which are based on probiotics and/or prebiotics, to shape the infant microbiota. In this review, we will present the current state of the art regarding the infant gut microbiota and the role of key commensal microorganisms like bifidobacteria in the establishment of the first microbial communities in the human gut.en
dc.description.statusPeer revieweden
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid16
dc.identifier.citationTurroni, F., Milani, C., Duranti, S. et al. (2020) 'The infant gut microbiome as a microbial organ influencing host well-being', Italian Journal of Pediatrics, 46,16 (13pp). doi: 10.1186/s13052-020-0781-0
dc.identifier.doi10.1186/s13052-020-0781-0en
dc.identifier.eissn1824-7288
dc.identifier.issued1
dc.identifier.journaltitleItalian Journal of Pediatrics
dc.identifier.startpage13
dc.identifier.urihttps://hdl.handle.net/10468/14455
dc.identifier.volume46
dc.language.isoenen
dc.publisherSpringer Nature
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::CSA/696300/EU/The second coordination and support action for the JPI Healthy Diet for a Healthy Life/CSA JPI HDHL 2.0
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/EU Joint Programming Initiative::A Healthy Diet for a Healthy Life JPI (HDHL-JPI)/15/JP-HDHL/3280/IE/Impact of early life on microbiome development and later health (EarlyMicroHealth)/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.rights© The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBifidobacteria
dc.subjectBifidobacterium bifidum PRL2010
dc.subjectMicrobiome
dc.subjectNeonates
dc.subjectProbiotics
dc.titleThe infant gut microbiome as a microbial organ influencing host well-beingen
dc.typeArticle (peer-reviewed)
Files
Collections
IRIS Collection
Load more