dc.contributor.author	Heneghan, Clara
dc.contributor.author	Kiely, Mairead E.
dc.contributor.author	Lyons, Jacqueline
dc.contributor.author	Lucey, Alice J.
dc.contributor.funder	Department of Agriculture, Food and the Marine	en
dc.date.accessioned	2018-02-23T15:18:53Z
dc.date.available	2018-02-23T15:18:53Z
dc.date.issued	2018-01-10
dc.date.updated	2018-02-23T15:03:51Z
dc.description.abstract	Scope: Epidemiological evidence, animal, and in vitro studies suggest that berry consumption may ameliorate markers of cardiovascular disease (CVD). The aim of this systematic review is to evaluate findings from berry-based randomized controlled trials (RCTs) to establish the effects of berry consumption on markers of cardiovascular and metabolic health. Methods and results: PubMed and Web of Science are searched for RCTs investigating berry consumption on CVD risk outcomes in adults. A total of 23 studies (which includes 1168 participants) out of 1384 records meet the inclusion criteria. Of these 23 studies, 17 RCTs are of high quality, where 12 RCTs (71%) report beneficial effects of berry consumption on CVD risk markers. Overall, 4/11 RCTs that observe a reduction in systolic and/or diastolic blood pressure (BP); 3/7 RCTs report favorable effects on endothelial function, 2/3 RCTs report improvements in arterial stiffness, 7/17 studies observe benefits in blood lipids, and 3/6 studies report improvements in glycemic profile. Conclusion: Our evaluation of the literature indicates that more than two-thirds of high-quality trials have reported beneficial effects of berry consumption on markers of CVD risk. This systematic review contributes moderate to strong evidence for the inclusion of berries as part of a cardioprotective diet.	en
dc.description.sponsorship	Department of Agriculture, Food and the Marine (grant 13F539)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Heneghan, C., Kiely, M., Lyons, J. and Lucey, A. (2018) 'The Effect of Berry-Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials', Molecular Nutrition & Food Research, 62(1), 1700645 (12pp). doi: 10.1002/mnfr.201700645	en
dc.identifier.doi	10.1002/mnfr.201700645
dc.identifier.endpage	1700645-12	en
dc.identifier.issn	1613-4133
dc.identifier.issued	1	en
dc.identifier.journaltitle	Molecular Nutrition & Food Research	en
dc.identifier.startpage	1700645-1	en
dc.identifier.uri	https://hdl.handle.net/10468/5543
dc.identifier.volume	62	en
dc.language.iso	en	en
dc.publisher	Wiley	en
dc.rights	© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: C. Heneghan, M. Kiely, J. Lyons, A. Lucey, ‘The Effect of Berry-Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials,’ Mol. Nutr. Food Res. 2018, 62, 1700645, which has been published in final form at http://dx.doi.org/10.1002/mnfr.201700645. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.	en
dc.subject	Berries	en
dc.subject	Cardiovascular risk	en
dc.subject	Dietary intervention	en
dc.subject	Randomized controlled trials	en
dc.title	The effect of berry-based food interventions on markers of cardiovascular and metabolic health: A systematic review of randomized controlled trials	en
dc.type	Article (peer-reviewed)	en

The effect of berry-based food interventions on markers of cardiovascular and metabolic health: A systematic review of randomized controlled trials

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