Electrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cells

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dc.contributor.authorFernandes, Philana
dc.contributor.authorO'Donovan, Tracey R.
dc.contributor.authorMcKenna, Sharon L.
dc.contributor.authorForde, Patrick F.
dc.contributor.funderPancreatic Cancer Research Funden
dc.date.accessioned2019-10-06T20:48:04Z
dc.date.available2019-10-06T20:48:04Z
dc.date.issued2019-08-14
dc.description.abstractPancreatic cancer represents a major challenge in oncology. Poor permeability of the pancreas and resistance to currently available therapies are impediments to improved patient survival. By transiently increasing cell membrane porosity and increasing drug uptake, Electrochemotherapy (ECT) has the potential to overcome these issues. In this study, we have evaluated the response of human and murine pancreatic cancer cells, in vitro, to electroporation in combination with Bleomycin, Cisplatin, or Oxaliplatin (ECT). The cytotoxic actions of all three drugs are potentiated when combined with electroporation in these cells. The biochemical and morphological changes post ECT are associated with immunogenic cell death that occurs with necroptosis rather than apoptosis. Moreover, ECT-induced cell death is rescued by Nec-1 suggesting that necroptosis may play a role in cell death mediated by cancer therapies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1177en
dc.identifier.citationFernandes, P., O’Donovan, T. R., McKenna, S. L. and Forde, P. F. (2019) 'Electrochemotherapy Causes Caspase-Independent Necrotic-Like Death in Pancreatic Cancer Cells', Cancers, 11(8), 1177. (21pp.) DOI: 10.3390/cancers11081177en
dc.identifier.doi10.3390/cancers11081177en
dc.identifier.eissn2072-6694
dc.identifier.endpage21en
dc.identifier.issued8en
dc.identifier.journaltitleCancersen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8699
dc.identifier.volume11en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.isreplacedbyhttps://www.mdpi.com/2072-6694/11/8/1177/htm
dc.rights© The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectECTen
dc.subjectNecroptosisen
dc.subjectApoptosisen
dc.subjectICDen
dc.subjectNecrostatin-1en
dc.titleElectrochemotherapy causes caspase-independent necrotic-like death in pancreatic cancer cellsen
dc.typeArticle (peer-reviewed)en
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