Gold nanoparticles enlighten the future of cancer theranostics

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dc.contributor.authorGuo, Jianfeng
dc.contributor.authorRahme, Kamil
dc.contributor.authorHe, Yan
dc.contributor.authorLi, Lin-Lin
dc.contributor.authorHolmes, Justin D.
dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.funderPeople's Government of Jilin Provinceen
dc.contributor.funderJilin Universityen
dc.contributor.funderConseil National de la Recherche Scientifiqueen
dc.contributor.funderNovartisen
dc.contributor.funderHaematology Association of Irelanden
dc.date.accessioned2017-09-20T15:43:11Z
dc.date.available2017-09-20T15:43:11Z
dc.date.issued2017-08
dc.date.updated2017-09-20T15:25:48Z
dc.description.abstractDevelopment of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.en
dc.description.sponsorshipPeople's Government of Jilin Province (Department of Science and Technology, Jilin Province (Outstanding Youth Foundation, Project Number: 20170520046JH)); Jilin University (Start-Up Research Grant Program (Project Number: 451160102052)); Haematology Association of Ireland and Novartis Oncology (HAI-Novartis Fellowship Award); Conseil National de la Recherche Scientifique, National Council for Scientific Research Lebanon (CNRS Lebanon GRP2015)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGuo, J., Rahme, K., He, Y., Li, L., Ho,lmes, J. D. and O'Driscoll, C. M. (2017) 'Gold nanoparticles enlighten the future of cancer theranostics'. International Journal of Nanomedicine, 12, pp. 6131-6152. doi: 10.2147/IJN.S140772en
dc.identifier.doi10.2147/IJN.S140772
dc.identifier.endpage6152en
dc.identifier.issn1178-2013
dc.identifier.journaltitleInternational Journal of Nanomedicineen
dc.identifier.startpage6131en
dc.identifier.urihttps://hdl.handle.net/10468/4753
dc.identifier.volume12en
dc.language.isoenen
dc.publisherDove Medical Pressen
dc.rights© 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectMultifunctional gold nanoparticlesen
dc.subjectCancer bioimagingen
dc.subjectCancer photothermal and photodynamic therapyen
dc.subjectNear-infrared lighten
dc.subjectScattering submicroscopic particlesen
dc.subjectEnhanced photothermal therapyen
dc.subjectHighly fluorescent analogsen
dc.subjectSurface-plasmon resonanceen
dc.subjectNucleic-acid deliveryen
dc.subjectIn-vivoen
dc.subjectPhotodynamic therapyen
dc.subjectOptical-propertiesen
dc.subjectSirna deliveryen
dc.titleGold nanoparticles enlighten the future of cancer theranosticsen
dc.typeArticle (peer-reviewed)en
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