Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative

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dc.contributor.authorHofman, Cynthia S.
dc.contributor.authorLutomski, Jennifer E.
dc.contributor.authorBoter, Han
dc.contributor.authorBuurman, Bianca M.
dc.contributor.authorde Craen, Anton J. M.
dc.contributor.authorDonders, Rogier
dc.contributor.authorOlde Rikkert, Marcel G. M.
dc.contributor.authorMakai, Peter
dc.contributor.authorMelis, René J. F.
dc.contributor.authorTOPICS-MDS research consortium
dc.contributor.funderZonMwen
dc.date.accessioned2017-04-10T10:34:29Z
dc.date.available2017-04-10T10:34:29Z
dc.date.issued2017-03-15
dc.date.updated2017-03-31T10:50:30Z
dc.description.abstractBackground: Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey—Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital). Methods: Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril’s ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression. Results: In the complete sample and when stratified by study setting TOPICS-CEP and Cantril’s ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup. Conclusion: This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care.en
dc.description.sponsorshipZonMw, The Netherlands (Dutch National Care for the Elderly Programme, Grant number: 60-61900-98-302)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide0173081
dc.identifier.citationHofman, C. S., Lutomski, J. E., Boter, H., Buurman, B. M., de Craen, A. J. M., Donders R., et al. (2017) ‘Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative’, PLoS ONE 12(3): e0173081 (12pp). doi:10.1371/journal.pone.0173081en
dc.identifier.doi10.1371/journal.pone.0173081
dc.identifier.endpage12en
dc.identifier.issn1932-6203
dc.identifier.issued3en
dc.identifier.journaltitlePlos Oneen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/3865
dc.identifier.volume12en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttps://doi.org/10.6084/m9.figshare.4697542.v1
dc.rights© 2017, Hofman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectQuality of lifeen
dc.subjectHealth statusen
dc.subjectPatient groupsen
dc.subjectCareen
dc.subjectAdultsen
dc.titleExamining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiativeen
dc.typeArticle (peer-reviewed)en
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