Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria

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dc.contributor.authorGutiérrez-Barranquero, José A.
dc.contributor.authorReen, F. Jerry
dc.contributor.authorParages, María L.
dc.contributor.authorMcCarthy, Ronan
dc.contributor.authorDobson, Alan D. W.
dc.contributor.authorO'Gara, Fergal
dc.contributor.funderEuropean Commissionen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderIrish Research Council for Science, Engineering and Technologyen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderMarine Instituteen
dc.contributor.funderTeagascen
dc.date.accessioned2019-10-06T20:57:35Z
dc.date.available2019-10-06T20:57:35Z
dc.date.issued2017-11-03
dc.description.abstractIn recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries. A combination of unique physicochemical properties and spatial niche‐specific substrates, in wide‐ranging and extreme habitats, underscores the potential of the marine environment to deliver on functionally novel bioactivities. One such area of ongoing research is the discovery of compounds that interfere with the cell–cell signalling process called quorum sensing (QS). Described as the next generation of antimicrobials, these compounds can target virulence and persistence of clinically relevant pathogens, independent of any growth‐limiting effects. Marine sponges are a rich source of microbial diversity, with dynamic populations in a symbiotic relationship. In this study, we have harnessed the QS inhibition (QSI) potential of marine sponge microbiota and through culture‐based discovery have uncovered small molecule signal mimics that neutralize virulence phenotypes in clinical pathogens. This study describes for the first time a marine sponge Psychrobacter sp. isolate B98C22 that blocks QS signalling, while also reporting dual QS/QSI activity in the Pseudoalteromonas sp. J10 and ParacoccusJM45. Isolation of novel QSI activities has significant potential for future therapeutic development, of particular relevance in the light of the pending perfect storm of antibiotic resistance meeting antibiotic drug discovery decline.en
dc.description.sponsorshipEuropean Commission (FP7-PEOPLE-2013-ITN, FP7-KBBE-2012-6, FP7-2012-6, OCEAN 2011-2); Science Foundation Ireland (SSPC-2); Department of Agriculture and Food (FIRM 08/RDC/629, FIRM 1/F009/MabS, FIRM 13/F/516); Irish Research Council for Science, Engineering and Technology (PD/2011/2414, GOIPG/2014/647); Health Research Board/ Irish Thoracic Society (MRCG-2014-6); Marine Institute (C2CRA 2007/082); Teagasc (Walsh Fellowship 2013).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGutiérrez-Barranquero, J. A., Reen, F. J., Parages, M. L., McCarthy, R., Dobson, A. D. W. and O'Gara, F. (2019) 'Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria', Microbial Biotechnology, 12(5), pp. 1049-1063. DOI: 10.1111/1751-7915.12867en
dc.identifier.doi10.1111/1751-7915.12867en
dc.identifier.eissn1751-7915
dc.identifier.endpage1063en
dc.identifier.issued5en
dc.identifier.journaltitleMicrobial Biotechnologyen
dc.identifier.startpage1049en
dc.identifier.urihttps://hdl.handle.net/10468/8703
dc.identifier.volume12en
dc.language.isoenen
dc.publisherJohn Wiley and Sons Ltden
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAINen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMAREen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA) - Training Award/13/TIDA/B2625 TIDA Training 2014/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2977/IE/Pre-clinical testing of novel fungal biofilm blockers for the medical device sector./en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.12867
dc.rights©2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectClinical pathogensen
dc.subjectMarine sponge bacteriaen
dc.subjectN-acyl-homoserineen
dc.subjectLactone-specific signallingen
dc.subjectMarine environmenten
dc.subjectBiotechnologicalen
dc.subjectPhysicochemical propertiesen
dc.subjectNovel bioactivitiesen
dc.subjectQuorum sensing (QS)en
dc.titleDisruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteriaen
dc.typeArticle (peer-reviewed)en
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