A randomised controlled trial to determine if the addition of capnography to standard monitoring results in a decreased incidence of hypoxaemia during conscious sedation for oral surgery

Simple item page
dc.check.date10000-01-01
dc.check.embargoformatE-thesis on CORA onlyen
dc.check.entireThesisEntire Thesis Restricted
dc.check.infoIndefiniteen
dc.check.opt-outYesen
dc.check.reasonThis thesis is due for publication or the author is actively seeking to publish this materialen
dc.contributor.advisorO'Halloran, Ken D.en
dc.contributor.advisorMcCreary, Christineen
dc.contributor.authorBrady, Paul
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2017-10-20T09:16:34Z
dc.date.issued2017
dc.date.submitted2017
dc.description.abstractBackground: Data from procedural sedation suggest that capnography is a more sensitive measure of ventilation than standard modalities and detects respiratory depression before hypoxaemia occurs. However, the generalisability of published research is problematic. To date, there has been no dentistry-specific published data supporting the use of monitoring with capnography for dental sedation. Our aim was to determine if adding capnography to standard monitoring during conscious sedation with Midazolam in a dental setting would decrease the incidence of hypoxaemia. Methods: A randomised controlled trial was conducted in which all patients (ASA I & II with BMI < 35 kg/m2) received standard monitoring and capnography, but were randomised to whether staff could view the capnography (intervention) or were blinded to it (control). The primary outcome was the incidence of hypoxaemia defined as a fall in oxygen saturation (SpO2) ≤ 94%. Results: 190 patients, mean age 31.3 years (range 14–62 years) were enrolled. There were 93 patients in the capnography group and 97 in the control group. The mean cumulative dose of Midazolam titrated was 6.94 mg (SD 2.31, range 3–20 mg). Six (3%) patients, three in each group, required temporary supplemental oxygen. There was no statistically significant difference between the capnography and control groups for the incidence of hypoxaemia: 34.4% vs 39.2% (p=0.5149, OR=0.78, 95% CI: 0.38–1.63). Conclusions: We were unable to confirm an additive role for capnography to prevent hypoxaemia during conscious sedation with Midazolam in a dental setting for patients not routinely administered supplemental oxygen. Clinical trial registration: ClinicalTrials.gov NCT01949012.en
dc.description.sponsorshipHealth Research Board (HPF/2013/458)en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBrady, P. 2017. A randomised controlled trial to determine if the addition of capnography to standard monitoring results in a decreased incidence of hypoxaemia during conscious sedation for oral surgery. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/4920
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2017, Paul Brady.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectCapnographyen
dc.subjectHypoxaemiaen
dc.subjectConscious sedationen
dc.thesis.opt-outtrue
dc.titleA randomised controlled trial to determine if the addition of capnography to standard monitoring results in a decreased incidence of hypoxaemia during conscious sedation for oral surgeryen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD (Dentistry)en
Files
License bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
license.txt
Size:
5.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Thumbnail Image
Name:
Paul Brady.pdf
Size:
33.79 KB
Format:
Adobe Portable Document Format
Description:
Opt-Out Form
Collections
Doctoral Theses
College of Medicine and Health - Doctoral Theses
Cork University Dental School and Hospital - Doctoral Theses