An exploration of the prognostic utility of shortened dynamic imaging protocols for PET-FDG scans

Simple item page
dc.contributor.authorWu, Qi
dc.contributor.authorO'Sullivan, Finbarr
dc.contributor.authorMuzi, Mark
dc.contributor.authorMankoff, David
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderNational Institutes of Healthen
dc.date.accessioned2020-09-25T12:43:05Z
dc.date.available2020-09-25T12:43:05Z
dc.date.issued2019-11
dc.date.updated2020-09-25T12:34:58Z
dc.description.abstractStandard whole-body clinical fluoro-deoxyglucose (FDG)-PET scans typically involve imaging for around 15 minutes about 60 minutes after tracer injection. The scan duration is often the critical constraint limiting patient through-put. Scans taken long after tracer injection restrict the ability to assess vascular and perfusion information that might be revealed by the early pattern of tracer uptake. On the other hand, early scanning may compromise the recovery of the late time uptake (SUV) which in many contexts has well established prognostic value. In this study, we explore the potential for short-duration dynamic scans, acquired immediately after tracer injection, to recover information that can predict late-stage uptake of FDG. The work involves re-analysis of existing series of dynamic brain and breast tumour imaging data to simulate the type of information that would arise from early and late scanning. Using a collection of machine learning techniques (including random forests, neural networks, gradient boosting), we find that short-duration clinical protocols, soon after the tracer injection, show significant potential to recover the late stage FDG flux information.en
dc.description.sponsorshipScience Foundation Ireland (Grant No. PI-11/1027); National Institutes of Health (National CancerInstitute USA grants R33-CA225310 and R50-CA221270.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWu, Q., O’Sullivan, F., Muzi, M. and Mankoff, D. A. (2019) 'An exploration of the prognostic utility of shortened dynamic imaging protocols for PET-FDG scans'. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 26 Oct.-2 Nov. 2019, 1-3. doi: 10.1109/NSS/MIC42101.2019.9059874en
dc.identifier.doi10.1109/NSS/MIC42101.2019.9059874en
dc.identifier.eissn2577-0829
dc.identifier.endpage3en
dc.identifier.isbn978-1-7281-4164-0
dc.identifier.isbn978-1-7281-4165-7
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10589
dc.language.isoenen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.urihttps://ieeexplore.ieee.org/document/9059874
dc.rights© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en
dc.subjectBlood vesselsen
dc.subjectBrainen
dc.subjectCanceren
dc.subjectHaemorheologyen
dc.subjectLearning (artificial intelligence)en
dc.subjectMedical image processingen
dc.subjectPositron emission tomographyen
dc.subjectTumoursen
dc.subjectPrognostic utilityen
dc.subjectPET-FDG scansen
dc.subjectWhole-body clinical fluoro-deoxyglucose-PET scansen
dc.subjectTracer injectionen
dc.subjectPrognostic valueen
dc.subjectShort-duration dynamic scansen
dc.subjectDynamic brainen
dc.subjectBreast tumouren
dc.subjectShort-duration clinical protocolsen
dc.subjectFDG flux informationen
dc.subjectDynamic imaging protocolsen
dc.subjectCritical constraint limiting patienten
dc.subjectNeural networken
dc.subjectGradient boostingen
dc.subjectRandom forestsen
dc.subjectTumorsen
dc.subjectImagingen
dc.subjectBlooden
dc.subjectKinetic theoryen
dc.subjectBreast canceren
dc.subjectPredictive modelsen
dc.titleAn exploration of the prognostic utility of shortened dynamic imaging protocols for PET-FDG scansen
dc.typeConference itemen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
An_exploration_of_the_prognostic_utility_of_shortened_dynamic_imaging_protocols_for_PET-FDG_scans.pdf
Size:
1.2 MB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Mathematical Sciences - Conference Items