Clinical outcomes of real-world Kalydeco (ivacaftor); Cork study - understanding the implications of CFTR modulation

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dc.availability.bitstreamembargoed
dc.check.date2022-09-30
dc.contributor.advisorPlant, Barryen
dc.contributor.advisorEustace, Joeen
dc.contributor.authorRonan, Nicola J.
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2021-09-15T14:56:45Z
dc.date.available2021-09-15T14:56:45Z
dc.date.issued2020-09-12
dc.date.submitted2020-09-12
dc.description.abstractCF represents one of the success stories of modern medicine with sustained incremental increases in survival from one of childhood death to one of adulthood survival. Traditionally the management of CF has focused on treating the consequences of CFTR dysfunction. The advent of ivacaftor offers the opportunity to evaluate the effect of restoration of CFTR function on CF lung disease and extrapulmonary manifestations. Global prevalence of the G551D mutation is 4%. Prevalance at Cork CF centre is 23%. Thus this work evaluates the effect of CFTR modulation on clinical parameters, Chest CT, lung microbiota, gut microbiota, gut inflammation, pancreatic function and benefit to the individual patient.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRonan, N. J. 2020. Clinical outcomes of real-world Kalydeco (ivacaftor); Cork study - understanding the implications of CFTR modulation. PhD Thesis, University College Cork.en
dc.identifier.endpage265en
dc.identifier.urihttps://hdl.handle.net/10468/11923
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/603038/EU/Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified./CFMATTERSen
dc.rights© 2020, Nicola J. Ronan.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCFTR modulationen
dc.subjectCystic fibrosisen
dc.subjectIvacaftoren
dc.titleClinical outcomes of real-world Kalydeco (ivacaftor); Cork study - understanding the implications of CFTR modulationen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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