Bacteria and bacterial-produced proteins as biomarker technology for precision oncology

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dc.check.chapterOfThesisChapter 3 should be redacted because of potential I.P. grounds.en
dc.check.date2026-09-30
dc.check.infoPartial Restriction
dc.contributor.advisorTangney, Mark
dc.contributor.authorDevoy, Ciaranen
dc.contributor.funderBreakthrough Cancer Research
dc.date.accessioned2025-05-16T11:16:26Z
dc.date.available2025-05-16T11:16:26Z
dc.date.issued2024
dc.date.submitted2024
dc.descriptionPartial Restriction
dc.description.abstractBiomarkers play a crucial role in cancer research, particularly in the context of precision oncology. A wide range of strategies exist to detect disease associated endogenous genes, proteins or activity. This thesis focuses on exploiting bacteria or bacterial-produced proteins in biomarker contexts. Chapter 2 describes the development of a detection system of biomarker activity, produced from bacteria; Chapter 3 describes development of a platform for deployment of biomarker detectors, produced from bacteria; while Chapter 4 examines the factors contributing to the success or failure of three clinical microbiome wide association studies (MWAS), in the context of patient accrual and the resources and systems required for set-up by measuring set-up time. Chapter 5 compares preliminary sequencing results of the MWAS in Chapter 4 to the current published literature.
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDevoy, C. 2024. Bacteria and bacterial-produced proteins as biomarker technology for precision oncology. PhD Thesis, University College Cork.
dc.identifier.endpage255
dc.identifier.urihttps://hdl.handle.net/10468/17510
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2024, Ciarán Devoy.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiomarkers
dc.subjectCancer
dc.subjectGut microbiome
dc.titleBacteria and bacterial-produced proteins as biomarker technology for precision oncology
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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