A comparison of flow- and pressure-controlled infusion strategies for microneedle-based transdermal drug delivery

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dc.contributor.authorSebastian, Ryan
dc.contributor.authorGuillerm, Theo
dc.contributor.authorTjulkins, Fjodors
dc.contributor.authorHu, Yuan
dc.contributor.authorClover, A. James P.
dc.contributor.authorLyness, Alexander
dc.contributor.authorO'Mahony, Conor
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderElectronic Components and Systems for European Leadershipen
dc.contributor.funderWest Pharmaceutical Services , Irelanden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020
dc.date.accessioned2022-09-27T11:06:54Z
dc.date.available2022-09-27T11:06:54Z
dc.date.issued2022-07-15
dc.date.updated2022-09-27T10:56:25Z
dc.description.abstractMicroneedle-based transdermal drug delivery is considered an attractive alternative to conventional injections using hypodermic needles due to its minimally invasive and painless nature; this has the potential to improve patient adherence to medication regimens. Hollow microneedles (MNs) are sharp, sub-millimeter protrusions with a channel that serves as a fluidic interface with the skin. This technology could be coupled with micro-pumps, embedded sensors, actuators and electronics to create Micro Transdermal Interface Platforms - smart, wearable infusion systems capable of delivering precise microdoses over a prolonged period. Using 500 µm tall hollow microneedles, ex-vivo human skin and a customized application/retraction device, this work focuses on comparing two infusion control strategies, namely ‘set pressure’ (SP) and ‘set flow’ (SF) infusion. It was found that flow-controlled infusion was capable of delivering higher volumes than pressure-driven delivery, and a mean volume of 3.8 mL was delivered using a set flowrate of 50 µL/minute. This suggests that flow driven delivery is a better control strategy and confirms that MN array retraction is beneficial for transdermal MN infusion.en
dc.description.sponsorshipEnterprise Ireland and the ECSEL Joint Undertaking (under grant number H2020-ECSEL-2019-IA-876190 (Moore4Medical)); Enterprise Ireland and West Pharmaceutical Services (under grant number IP2017/0560); Science Foundation Ireland (SFI Insight Centre for Data Analytics (SFI/12/RC/2289-P2))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRyan, S., Guillerm, T., Tjulkins, F., Hu, Y., Clover, J. A. P., Lyness, A. and O'Mahony, C. (2022) 'A Comparison of Flow- and Pressure-Controlled Infusion Strategies for Microneedle-based Transdermal Drug Delivery', EMBEC 2022, 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society, Glasgow, Scotland, UK, 11-15 July, pp. 2573-2576. doi: 10.1109/EMBC48229.2022.9871582en
dc.identifier.doi10.1109/EMBC48229.2022.9871582en
dc.identifier.eissn2694-0604
dc.identifier.endpage2576en
dc.identifier.isbn978-1-7281-2782-8
dc.identifier.issn2375-7477
dc.identifier.startpage2573en
dc.identifier.urihttps://hdl.handle.net/10468/13672
dc.language.isoenen
dc.publisherIEEEen
dc.relation.ispartof2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::ECSEL-IA/876190/EU/Accelerating Innovation in Microfabricated Medical Devices/Moore4Medicalen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2289/IE/INSIGHT - Irelands Big Data and Analytics Research Centre/en
dc.relation.urihttps://doi.org/10.1109/EMBC48229.2022.9871582
dc.rights© 2022 The Authors. This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectElectric potentialen
dc.subjectMinimally invasive surgeryen
dc.subjectDrug deliveryen
dc.subjectSkinen
dc.subjectSiliconen
dc.subjectSensor systemsen
dc.subjectHypodermic needlesen
dc.subject~Tyndall National Institute - Conference Items~en
dc.titleA comparison of flow- and pressure-controlled infusion strategies for microneedle-based transdermal drug deliveryen
dc.typeConference itemen
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