Investigation of the function of the LNX family of E3 ubiquitin ligases in the nervous system

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dc.check.date10000-01-01
dc.check.embargoformatBoth hard copy thesis and e-thesisen
dc.check.entireThesisEntire Thesis Restricted
dc.check.infoIndefiniteen
dc.check.opt-outYesen
dc.check.reasonThis thesis is due for publication or the author is actively seeking to publish this materialen
dc.contributor.advisorYoung, Paulen
dc.contributor.authorSaha, Orthis
dc.date.accessioned2013-07-18T12:01:41Z
dc.date.issued2013
dc.date.submitted2013
dc.description.abstractThe Lnx1 (Ligand of Numb protein X 1) and Lnx2 genes belong to a family of PDZ domain-containing RING finger domain E3 ubiquitin ligases. mRNA expression for both genes have been reported in early murine central nervous system. However, there have been limited reports with regards to the expression patterns for both the proteins in vivo. Hence, we have attempted to characterize the significance of these proteins in the context of morphology and physiology of the central nervous system. Through our studies, we have attempted to examine closely the expression of these two genes in the murine central nervous system. We have also looked at novel interacting ligands for both proteins. Interacting partners have been examined with particular relevance to possible roles of their interactions with LNX1 and LNX2 in the functioning of the nervous system. Moreover, we have performed loss-of-function studies by way of creation and characterization of knockout mice.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSaha, O. 2013. Investigation of the function of the LNX family of E3 ubiquitin ligases in the nervous system. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/1195
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2013, Orthis Sahaen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectLNX1en
dc.subjectLNX2en
dc.subjectMurine central nervous systemen
dc.subjectmRNA expressionen
dc.subject.lcshMice--Physiologyen
dc.subject.lcshGene expressionen
dc.subject.lcshCentral nervous systemen
dc.thesis.opt-outtrue*
dc.titleInvestigation of the function of the LNX family of E3 ubiquitin ligases in the nervous systemen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD (Science)en
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