Iron status in early life and associations with developmental outcomes

Simple item page
dc.check.embargoformatNot applicableen
dc.check.infoNo embargo requireden
dc.check.opt-outYesen
dc.check.reasonNo embargo requireden
dc.check.typeNo Embargo Required
dc.contributor.advisorKiely, Maireaden
dc.contributor.advisorMurray, Deirdre M.en
dc.contributor.authorMcCarthy, Elaine K.
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.contributor.funderDanone Nutricia Early Life Nutrition, Irelanden
dc.date.accessioned2016-05-13T11:39:15Z
dc.date.available2016-05-13T11:39:15Z
dc.date.issued2016
dc.date.submitted2016
dc.description.abstractInfants and young children are at particular risk of iron deficiency and its associated consequences for growth and development. The main objectives of this thesis were to quantify iron intakes, status and determinants of status in two year olds; explore determinants of neonatal iron stores; investigate associations between iron status at birth and two years with neurodevelopmental outcomes at two years and explore the influence of growth on iron status in early childhood, using data from the Cork BASELINE (Babies after SCOPE: Evaluating Longitudinal Impact using Neurological and Nutritional Endpoints) Birth Cohort Study (n=2137). Participants were followed prospectively with interviewer-led questionnaires and clinical assessments at day 2 and at 2, 6, 12 and 24 months. At two years, there was a low prevalence of iron deficiency and iron deficiency anaemia in this cohort, representing the largest study of iron status in toddlers in Europe, to date. The increased consumption of iron-fortified products and compliance with recommendations to limit unmodified cows’ milk intakes in toddlers has contributed to the observed improvements in status. Low serum ferritin concentrations at birth, which reflect neonatal iron stores, were shown to track through to two years of age; delivery by Caesarean section, being born small-for-gestational age and maternal obesity and smoking in pregnancy were all associated with significantly lower neonatal iron stores. Despite a low prevalence of iron deficiency in this cohort, both a mean corpuscular volume <74fl and ferritin concentrations <20μg/l were associated with lower neurodevelopmental outcomes at two years. An inverse association between growth in the second year of life and iron status at two years was also observed. This thesis has presented data from one of the largest, extensively-characterised cohorts of young children, to date, to explore iron and its associations with growth and development.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcCarthy, E.K. 2016. Iron status in early life and associations with developmental outcomes. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/2554
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2016, Elaine K. McCarthy.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectBirth cohorten
dc.subjectIron deficiencyen
dc.subjectGrowthen
dc.subjectNeurodevelopmenten
dc.subjectCognitionen
dc.subjectIron storesen
dc.subjectIron intakesen
dc.subjectAnaemiaen
dc.subjectInfancyen
dc.subjectChildhooden
dc.thesis.opt-outtrue
dc.titleIron status in early life and associations with developmental outcomesen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD (Food Science and Technology)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CORA abstract.pdf
Size:
71.12 KB
Format:
Adobe Portable Document Format
Description:
Abstract
Download
License bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
license.txt
Size:
5.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Thumbnail Image
Name:
Decision To Withold EThesis Summer 2016 Elaine McCarthy.pdf
Size:
27.09 KB
Format:
Adobe Portable Document Format
Description:
Opt-out
Collections
Doctoral Theses
College of Science, Engineering and Food Science - Doctoral Theses
Food and Nutritional Sciences - Doctoral Theses