New insights of Raman spectroscopy for oral clinical applications

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dc.contributor.authorde Carvalho, Luis Felipe das Chagas e Silva
dc.contributor.authorSaito Nogueira, Marcelo
dc.contributor.funderFundação de Amparo à Pesquisa do Estado de São Pauloen
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superioren
dc.date.accessioned2020-02-21T10:01:07Z
dc.date.available2020-02-21T10:01:07Z
dc.date.issued2018-10-23
dc.description.abstractOral injuries are currently diagnosed by histopathological analysis of biopsy, which is an invasive procedure and does not give immediate results. On the other hand, the Raman spectroscopy technique is a real-time and minimally invasive analytical tool with a notable diagnostic capability. At the current stage, researchers are widely aware of the diagnostic potential of the technique and how it is considered promising for providing biochemical information in real time and without damaging the tissue. The problem originates from a lack of relevant studies and clinical trials that could show the actual use of Raman spectroscopy to help patients. Our goal here is to narrow the relationship between physicists, chemists, engineers, computer scientists, and the medical community, and in fact discuss the potential of Raman spectroscopy as a novel clinical analysis method. In the present study, we focused on the use of Raman spectroscopy as a daily clinical practice. In this context, additional studies and in vivo tests should be performed with the same approach as a real application. We want to show the scientific and industrial community what is really necessary for this, starting from a clinical point of view. Using our previous experience publishing different oral pathologies and types of samples, we also aim to discuss the current state and potential of Raman spectroscopy and what is required to implement Raman spectroscopy for oral clinical applications.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP – 2014/ 05978-1 and 2018/03636-7); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES PNPD – Odontologia UNITAU, Centro Universitário Braz Cubas by the Scientific Initiation Program and CLIRSPEC for SPEC 2018)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationde Carvalho, L. F. d. C. e. S. and Saito Nogueira, M. (2018) 'New insights of Raman spectroscopy for oral clinical applications', Analyst, 143(24), pp. 6037-6048. doi: 10.1039/C8AN01363Ben
dc.identifier.doi10.1039/C8AN01363Ben
dc.identifier.endpage6048en
dc.identifier.issn0003-2654
dc.identifier.issn1364-5528
dc.identifier.issued24en
dc.identifier.journaltitleAnalysten
dc.identifier.startpage6037en
dc.identifier.urihttps://hdl.handle.net/10468/9681
dc.identifier.volume143en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.rights© The Royal Society of Chemistry 2018en
dc.subjectDevicesen
dc.subjectLaboratory techniqueen
dc.subjectMouth diseaseen
dc.subjectProceduresen
dc.subjectRaman spectrometryen
dc.subjectClinical laboratory techniquesen
dc.subjectSpectrum analysis, ramanen
dc.titleNew insights of Raman spectroscopy for oral clinical applicationsen
dc.typeArticle (peer-reviewed)en
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