LC3B globular structures correlate with survival in esophageal adenocarcinoma

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dc.contributor.authorEl-Mashad, Shereen M.
dc.contributor.authorO'Donovan, Tracey R.
dc.contributor.authorKay, Elaine W.
dc.contributor.authorAbdallah, Ayat R.
dc.contributor.authorCathcart, Mary-Clare
dc.contributor.authorO'Sullivan, Jacintha
dc.contributor.authorO'Grady, Anthony
dc.contributor.authorReynolds, John
dc.contributor.authorO'Reilly, Seamus
dc.contributor.authorO'Sullivan, Gerald C.
dc.contributor.authorMcKenna, Sharon L.
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderBreakthrough Cancer Research, Irelanden
dc.contributor.funderEgyptian Education Bureauen
dc.date.accessioned2016-01-14T16:40:07Z
dc.date.available2016-01-14T16:40:07Z
dc.date.issued2015-08-12
dc.description.abstractBackground: Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome. Methods: Esophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and 48 patients post neoadjuvant therapy were assembled into tissue microarrays prior to immunohistochemical analysis. Kaplan-Meier survival curves and log-rank tests were used to assess impact of LC3B expression on survival. Cox regression was used to examine association with clinical risk factors. Results: A distinct globular pattern of LC3B expression was found to be predictive of outcome in both patient groups, irrespective of treatment (p < 0.001). Multivariate analysis found that this was a strong independent predictor of poor prognosis (p < 0.001). Conclusions: This distinctive staining pattern of LC3B represents a novel prognostic marker for resectable esophageal adenocarcinoma.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid582
dc.identifier.citationEL-MASHED, S., O’DONOVAN, T. R., KAY, E. W., ABDALLAH, A. R., CATHCART, M.-C., O’SULLIVAN, J., O’GRADY, A., REYNOLDS, J., O’REILLY, S., O’SULLIVAN, G. C. & MCKENNA, S. L. 2015. LC3B globular structures correlate with survival in esophageal adenocarcinoma. BMC Cancer, 15:582, 1-12. http://dx.doi.org/10.1186/s12885-015-1574-5en
dc.identifier.doi10.1186/s12885-015-1574-5
dc.identifier.endpage12en
dc.identifier.issn1471-2407
dc.identifier.journaltitleBMC Canceren
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/2185
dc.identifier.volume15en
dc.language.isoenen
dc.publisherBiomed Central Ltd.en
dc.rights© 2015 El-Mashed et al.; licensee BioMed Central Ltd. 2015. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectStone like structuresen
dc.subjectLight chain 3ben
dc.subjectCancer cellsen
dc.subjectPrognostic relevanceen
dc.subjectMarkers beclin-1en
dc.subjectBreast-canceren
dc.subjectAutophagyen
dc.subjectCarcinomasen
dc.subjectLC3B proteinen
dc.subjectCell viabilityen
dc.subjectLymph node metastasisen
dc.subjectLymph vessel metastasisen
dc.subjectMajor clinical studyen
dc.subjectOverall survivalen
dc.subjectPerineural invasionen
dc.subjectRetrospective studyen
dc.subjectSurvival timeen
dc.subjectTreatment outcomeen
dc.subjectTumor differentiationen
dc.subjectMicrotubule associated proteinen
dc.subjectAntibody specificityen
dc.subjectCancer adjuvant therapyen
dc.subjectCancer survivalen
dc.subjectEsophageal adenocarcinomaen
dc.titleLC3B globular structures correlate with survival in esophageal adenocarcinomaen
dc.typeArticle (peer-reviewed)en
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