The search for clinically useful biomarkers of complex disease: A data analysis perspective

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dc.contributor.authorConsidine, Elizabeth C.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-11-04T11:44:42Z
dc.date.available2019-11-04T11:44:42Z
dc.date.issued2019-07-02
dc.description.abstractUnmet clinical diagnostic needs exist for many complex diseases, which it is hoped will be solved by the discovery of metabolomics biomarkers. However, as yet, no diagnostic tests based on metabolomics have yet been introduced to the clinic. This review is presented as a research perspective on how data analysis methods in metabolomics biomarker discovery may contribute to the failure of biomarker studies and suggests how such failures might be mitigated. The study design and data pretreatment steps are reviewed briefly in this context, and the actual data analysis step is examined more closely.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid126en
dc.identifier.citationConsidine, E.C., 2019. The Search for Clinically Useful Biomarkers of Complex Disease: A Data Analysis Perspective. Metabolites, 9(7), 126. (14 pp.). DOI:10.3390/metabo9070126en
dc.identifier.doi10.3390/metabo9070126en
dc.identifier.eissn2218-1989
dc.identifier.endpage14en
dc.identifier.issn2218-1989
dc.identifier.issued7en
dc.identifier.journaltitleMetabolitesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8950
dc.identifier.volume9en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://www.mdpi.com/2218-1989/9/7/126
dc.rights© 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectComplex diseaseen
dc.subjectHeterogeneous diseaseen
dc.subjectBiomarker discoveryen
dc.subjectData analysisen
dc.subjectMetabolomicsen
dc.subjectReproducibilityen
dc.subjectModelingen
dc.subjectPrecision medicineen
dc.titleThe search for clinically useful biomarkers of complex disease: A data analysis perspectiveen
dc.typeArticle (peer-reviewed)en
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