Synthesis of iminophosphine and phosphinoiminol cyclometallated Pt (II) and Pt (IV) chloro complexes and studies into their biological and photophysical properties

O'Donoghue, John Daniel

Synthesis of iminophosphine and phosphinoiminol cyclometallated Pt (II) and Pt (IV) chloro complexes and studies into their biological and photophysical properties

dc.check.embargoformat	E-thesis on CORA only	en
dc.check.entireThesis	Entire Thesis Restricted
dc.check.opt-out	Yes	en
dc.check.reason	This thesis is due for publication or the author is actively seeking to publish this material	en
dc.contributor.advisor	Ní Dhubhghaill, Orla M.	en
dc.contributor.author	O'Donoghue, John Daniel
dc.contributor.funder	Kerry County Council	en
dc.contributor.funder	Higher Education Authority	en
dc.date.accessioned	2014-01-09T11:41:34Z
dc.date.available	2015-01-10T05:00:05Z
dc.date.issued	2013
dc.date.submitted	2013
dc.description.abstract	This thesis focuses on the synthesis and analysis of novel chloride based platinum complexes derived from iminophosphine and phosphinoamide ligands, along with studies on their reactivity towards substitution and oxidation reactions. Also explored here are the potential applications of these complexes for biological and luminescent purposes. Chapter one provides an extensive overview of platinum coordination chemistry with examples of various mixed donor ligands along with the history of platinum anticancer therapy. It also looks at metals in medicine, both for biological functions as well as for therapeutic purposes and gives a background to some other applications for platinum complexes. Chapter two outlines the design and synthetic strategies employed for the development of novel platinum (II) chloride complexes from iminophosphine and phosphinoamide ligands. Also reported is the cyclometallation of these complexes to form stable tridentate mixed donor platinum (II) compounds. In Chapter three the development of a direct method for displacing a chloride from a platinum metal centre with a desired phosphine is reported. Numerous methods for successful oxidation of the platinum (II) complexes will also be explored, leading to novel platinum (IV) complexes being reported here also. The importance of stabilisation of the displaced anion, chloride, by the solvent system will also be discussed in this chapter. Chapter four investigates the reactivity of the platinum (II) complexes towards two different biomolecules to form novel platinum bio-adducts. The potential application of the platinum (II) cyclometallates as chemotherapeutics will also be explored here using in-vitro cancer cell testing. Finally, luminescence studies are also reported here for the ligands and platinum complexes reported in chapter two and three to investigate potential applications in this field also. Chapter five provides a final conclusion and an overall summary of the entire project as well as identifying key areas for future work.	en
dc.description.status	Not peer reviewed	en
dc.description.version	Accepted Version
dc.format.mimetype	application/pdf	en
dc.identifier.citation	O'Donoghue, J. D. 2013. Synthesis of iminophosphine and phosphinoiminol cyclometallated Pt (II) and Pt (IV) chloro complexes and studies into their biological and photophysical properties. PhD Thesis, University College Cork.	en
dc.identifier.endpage	331
dc.identifier.uri	https://hdl.handle.net/10468/1298
dc.language.iso	en	en
dc.publisher	University College Cork	en
dc.rights	© 2013, John D. O'Donoghue.	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	en
dc.subject	Chemistry	en
dc.subject.lcsh	Coordination compounds	en
dc.subject.lcsh	Platinum compounds--Therapeutic use	en
dc.subject.lcsh	Chemistry, Inorganic	en
dc.subject.lcsh	Platinum	en
dc.thesis.opt-out	false
dc.title	Synthesis of iminophosphine and phosphinoiminol cyclometallated Pt (II) and Pt (IV) chloro complexes and studies into their biological and photophysical properties	en
dc.type	Doctoral thesis	en
dc.type.qualificationlevel	Doctoral	en
dc.type.qualificationname	PhD (Science)	en
ucc.workflow.supervisor	o.nidhubhghaill@ucc.ie