Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.

Simple item page
dc.contributor.authorHegarty, Shane V.
dc.contributor.authorO'Keefe, Gerard W.
dc.contributor.authorSullivan, Aideen M.
dc.contributor.funderIrish Research Councilen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2017-02-13T15:34:24Z
dc.date.available2017-02-13T15:34:24Z
dc.date.issued2014-10
dc.date.updated2017-02-13T15:17:43Z
dc.description.abstractNeuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson’s disease. In Parkinson’s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.en
dc.description.sponsorshipIrish Research Council (R13702 and R15897); Health Research Board of Ireland (HRA/2009/127); Science Foundation Ireland (10/RFP/NES27860)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHegarty, S.V., O’Keeffe, G.W. and Sullivan, A. M. (2014) 'Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease', Neural Regeneration Research, 9(19), pp. 1708-1711. doi:10.4103/1673-5374.143410en
dc.identifier.doi10.4103/1673-5374.143410
dc.identifier.endpage1711en
dc.identifier.issn1673-5374
dc.identifier.issued19en
dc.identifier.journaltitleNeural Regeneration Researchen
dc.identifier.startpage1708en
dc.identifier.urihttps://hdl.handle.net/10468/3623
dc.identifier.volume9en
dc.language.isoenen
dc.publisherMedknow Publicationsen
dc.rights© Neural Regeneration Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/en
dc.subjectNeuroprotectionen
dc.subjectNeurotrophic factorsen
dc.subjectNervous system development;en
dc.subjectNigrostriatal dopaminergic neuronsen
dc.subjectGlial cell line-derived neurotrophic factoren
dc.subjectNeurturinen
dc.subjectGrowth/differentiation factor 5en
dc.subjectParkinson's diseaseen
dc.titleNeurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.en
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2525.pdf
Size:
428.32 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Anatomy and Neuroscience - Journal Articles
Neonatal Brain Research Group - Journal Articles