Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population

dc.contributor.authorSaid, Joanne M.
dc.contributor.authorBrennecke, Shaun P.
dc.contributor.authorMoses, Eric K.
dc.contributor.authorWalker, Susan P.
dc.contributor.authorBorg, Anthony J.
dc.contributor.authorWilliams, Jeff T.
dc.contributor.authorHiggins, John R.
dc.date.accessioned2011-12-19T11:37:18Z
dc.date.available2011-12-19T11:37:18Z
dc.date.copyright2006
dc.date.issued2006-08
dc.date.updated2011-12-19T09:57:02Z
dc.description.abstractDifferences in the prevalence of thrombophilias in different ethnic populations have been demonstrated. Because the Australian population includes many different ethnic groups, we sought to assess the effect of ethnicity in our Australian prenatal population on the prevalence of thrombophilic polymorphisms. Asymptomatic, nulliparous women (n = 1,129) recruited for a large prospective study were included in this analysis. These women had no personal or family history of venous thromboembolism and were not known to be carrying an inherited or acquired thrombophilia. Ethnicity was determined at recruitment, and women were categorized as being of Northern European, Southern European, Middle Eastern, Asian, or Other ethnicity. These women underwent genotyping for the following polymorphisms: factor V Leiden G1691A, prothrombin gene A20210G mutation, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, and thrombomodulin C1418T. The factor V Leiden allele was seen significantly more frequently in patients of Middle Eastern background compared to those of Northern European and Asian ethnicity (p < 0.05). The prothrombin gene mutation was seen significantly more frequently in patients of Southern European ethnicity compared to those of Northern European or Asian ethnicity (p < 0.05). The MTHFR C677T allele (mutant) was significantly less common in those of Asian ethnicity compared to patients of Northern European and Southern European ethnicity (p < 0.0005). There were no significant differences seen with the MTHFR A1298C polymorphism. The mutant thrombomodulin allele was seen significantly more frequently in Asian women compared to Northern European, Southern European, or Middle Eastern women (p < 0.005). There are important ethnic differences in the prevalence of thrombophilic polymorphisms in the Australian prenatal population.en
dc.description.sponsorshipKings Jubilee Fund (City of Melbourne); the Royal Womens Hospital; University of Melbourne (Australian Postgraduate Award and Felix Meyer Scholarship)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSaid JM; Brennecke SP; Moses EK; Walker SP; Borg AJ; Williams JT; Higgins JR; (2006) 'Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population'. Human biology; an international record of research, 78 (4):403-412.en
dc.identifier.doi10.1353/hub.2006.0058
dc.identifier.endpage412en
dc.identifier.issn1534-6617
dc.identifier.issn0018-7143
dc.identifier.issued4en
dc.identifier.journaltitleHuman biologyen
dc.identifier.startpage403en
dc.identifier.urihttps://hdl.handle.net/10468/480
dc.identifier.volume78en
dc.language.isoenen
dc.publisherThe Wayne State University Pressen
dc.relation.urihttp://muse.jhu.edu/journals/human_biology/v078/78.4said.html
dc.rightsCopyright © 2006 by The Wayne State University Press. All rights reserved.en
dc.subjectThrombophiliaen
dc.subjectFactor V Leidenen
dc.subjectProthrombin geneen
dc.subjectMethylenetetrahydrofolate reductase (MTHFR)en
dc.subjectThrombomodulinen
dc.subjectAustraliaen
dc.subjectPrenatal populationen
dc.subject.lcshThromboembolismen
dc.subject.lcshPregnancyen
dc.titleEthnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal populationen
dc.typeArticle (peer-reviewed)en
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