Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease

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dc.contributor.authorCostello, Daniel J.
dc.contributor.authorO'Keeffe, Gerard W.
dc.contributor.authorHurley, Fiona M.
dc.contributor.authorSullivan, Aideen M.
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2017-12-14T10:17:23Z
dc.date.available2017-12-14T10:17:23Z
dc.date.issued2012-09-26
dc.date.updated2017-12-07T09:46:11Z
dc.description.abstractGrowth/differentiation factor 5 (GDF5) is a neurotrophic factor that promotes the survival of midbrain dopaminergic neurons in vitro and in vivo and as such is potentially useful in the treatment of Parkinson's disease (PD). This study shows that a continuous supply of GDF5, produced by transplanted GDF5-overexpressing CHO cells in vivo, has neuroprotective and neurorestorative effects on midbrain dopaminergic neurons following 6-hydroxydopamine (6-OHDA)-induced lesions of the adult rat nigrostriatal pathway. It also increases the survival and improves the function of transplanted embryonic dopaminergic neurons in the 6-OHDA-lesioned rat model of PD. This study provides the first proof-of-principle that sustained delivery of GDF5 in vivo may be useful in the treatment of PD.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCostello, D. J., O'Keeffe, G. W., Hurley, F. M. and Sullivan, A. M. (2012) ‘Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease’, Journal of Cellular and Molecular Medicine, 16(10), pp. 2451-2460. doi:10.1111/j.1582-4934.2012.01562.xen
dc.identifier.doi10.1111/j.1582-4934.2012.01562.x
dc.identifier.endpage2460en
dc.identifier.issn1582-4934
dc.identifier.issued10en
dc.identifier.journaltitleJournal of Cellular and Molecular Medicineen
dc.identifier.startpage2451en
dc.identifier.urihttps://hdl.handle.net/10468/5175
dc.identifier.volume16en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.rights© 2012, the Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectGrowth/differentiation factor 5en
dc.subjectNeurotrophic factoren
dc.subjectParkinson's diseaseen
dc.subjectNeurodegenerationen
dc.subjectDopamineen
dc.titleTransplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's diseaseen
dc.typeArticle (peer-reviewed)en
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