Exploring height outcomes with adjuvant aromatase inhibition in growth hormone–deficient male survivors of childhood cancer

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dc.check.date2025-05-28en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorPollock, Netanya I.en
dc.contributor.authorSong, Minkeunen
dc.contributor.authorWolf, Alexander J.en
dc.contributor.authorLi, Yimeien
dc.contributor.authorHawkes, Colin P.en
dc.contributor.authorMotamedi, Niloofaralsadaten
dc.contributor.authorDenburg, Michelle R.en
dc.contributor.authorMostoufi‐Moab, Sogolen
dc.date.accessioned2025-01-08T14:24:07Z
dc.date.available2025-01-08T14:24:07Z
dc.date.issued2024-05-28en
dc.description.abstractBackground: Aromatase inhibitors (AI) may improve height in short stature conditions; however, the effect in childhood cancer survivors (CCS) is unknown. We assessed final adult height (FAH) in CCS treated with AI and GH compared with those treated with GH alone. Methods: Retrospective cohort study of GH-deficient male CCS treated between 2007 and 2023. FAH was noted as the height at the fusion of growth plates or 18 years of age. Multivariable linear regression was used to examine treatment association with FAH, adjusting for other risk factors. Results: Ninety-two patients were included; 70 were treated with GH and 22 with combination AI/GH. The mean age at GH initiation did not differ between groups. The mean age at AI initiation was 13.7 ± 1.9 years. A greater proportion of patients in the AI/GH group were treated with stem cell transplantation, abdominal radiation, total body irradiation, and cis-retinoic acid (p < .01). Multivariable linear regression demonstrated no significant treatment association with FAH Z-score (β = 0.04, 95% CI: −0.9 to 0.9). History of spinal radiation (β = −0.93, 95% CI: −1.7 to −0.2), lower starting height Z-score (β = −0.8, 95% CI: −1.2 to −0.4), and greater difference between bone age and chronological age (β = −0.3, 95% CI: −0.5 to −0.07) were associated with lower FAH Z-score. Conclusions: Adjuvant AI was not associated with increased FAH in male CCS compared with GH monotherapy. Future work is needed to determine the optimal adjunctive treatment to maximize FAH for this population.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide31117en
dc.identifier.citationPollock, N. I., Song, M., Wolf, A. J., Li, Y., Hawkes, C. P., Motamedi, N., Denburg, M. R. and Mostoufi‐Moab, S. (2024) 'Exploring height outcomes with adjuvant aromatase inhibition in growth hormone–deficient male survivors of childhood cancer', Pediatric Blood and Cancer, 71(8), e31117 (9pp). https://doi.org/10.1002/pbc.31117en
dc.identifier.doihttps://doi.org/10.1002/pbc.31117en
dc.identifier.eissn1545-5017en
dc.identifier.endpage9en
dc.identifier.issn1545-5009en
dc.identifier.issued8en
dc.identifier.journaltitlePediatric Blood and Canceren
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16793
dc.identifier.volume71en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.rights© 2024, Wiley Periodicals LLC.This is the accepted version of the following item: Pollock, N. I., Song, M., Wolf, A. J., Li, Y., Hawkes, C. P., Motamedi, N., Denburg, M. R. and Mostoufi‐Moab, S. (2024) 'Exploring height outcomes with adjuvant aromatase inhibition in growth hormone–deficient male survivors of childhood cancer', Pediatric Blood and Cancer, 71(8), e31117 (9pp), which has been published in final form at: https://doi.org/10.1002/pbc.31117. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectAromatase inhibitoren
dc.subjectChildhood cancer survivoren
dc.subjectFinal adult heighten
dc.subjectGrowth hormone deficiencyen
dc.titleExploring height outcomes with adjuvant aromatase inhibition in growth hormone–deficient male survivors of childhood canceren
dc.typeArticle (peer-reviewed)en
oaire.citation.issue8en
oaire.citation.volume71en
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